BACKGROUND/AIMS 9-[2-(phosphonomethoxy)ethyl]guanine (PMEG) is one of the most active antiproliferative compounds in a series of acyclic nucleoside phosphonates and is active in intraperitoneal P388 tumors in mice. METHODS We synthesized octadecyloxyethyl (ODE) and hexadecyloxypropyl esters of PMEG and compared their antiproliferative activity with unmodified PMEG in primary human fibroblasts...

It is known that non-isomorphic coupled cell networks can have equivalent dynamics. Such networks are said to be ODE-equivalent and are related by a linear algebra condition involving their graph adjacency matrices. A network in an ODE-equivalence class is said to be minimal if it has a minimum number of edges. When studying a given network in an ODE-class it can be of great value to study inst...

در این مقاله یک مدل ریاضی برای مسئله سیستم تولیدی همکارانه ساخت بر اساس سفارش با رعایت انصاف تخصیص بار‌های تولید طراحی شده است. اهداف اصلی مدل، کمینه‌سازی هزینه‌‌های کل و حداکثر استفاده از منابع به‌منظور عادلانه شرایط عدم­قطعیت کنترل پارامتر‌های غیرقطعی روش برنامه‌ریزی فازی ‌شده نتایج نشان می‌دهد افزایش نرخ عدم‌قطعیت، می­یابد. ازآنجاکه ظرفیت کارخانه‌ها ثابت است، مقدار تقاضا، هر کارخانه نیز می­ی...

Der ständig zunehmende Einsatz verteilter DV-Systeme führt zu einem stark steigenden Bedarf an verteilten Anwendungen. Deren Entwicklung in den verschiedensten Anwendungsfeldern wie Fabrikund Büroautomatisierung ist für die Anwender bislang kaum zu handhaben. Neue Konzepte des Software Engineering sind daher notwendig, und zwar in den drei Bereichen ‘Sprachen’, ‘Werkzeuge’ und ‘Umgebungen’. Obj...

The relationships existing between MP graphs, metabolic P systems, and ODE systems are investigated. Formal results show that every MP system, once derived by its MP graph, results in an ODE system whose solution equals, in the limit, the solution obtained by a non-cooperative MP system that is ODE equivalent to the original one. The freedom of choice of the ODE equivalent from the original MP ...

3 Example: Differentiating the Lotka-Volterra ODE system 2 3.1 The Lotka-Volterra ODE system . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 3.2 The derivatives of the Lotka-Volterra ODE system . . . . . . . . . . . . . . . . . . 3 3.3 Integration of the original and augmented Lotka-Volterra ODE system with the Runge-Kutta method . . . . . . . . . . . . . . . . . . . . . . . . . . . ....

Integrating various suppliers to satisfy market demand is of great importance for e ective supply chain management. In this paper, we consider the ODE-PDE model of supply chain and apply a classical explicit fourth-order Runge-Kutta scheme for the related ODE model of suppliers. Also, the convergence of the proposed method is proved. Finally a numerical example is studied to demonstrate the acc...

Modeling dynamical systems with ordinary differential equations implies a mechanistic view of the process underlying the dynamics. However in many cases, this knowledge is not available. To overcome this issue, we introduce a general framework for nonparametric ODE models using penalized regression in Reproducing Kernel Hilbert Spaces (RKHS) based on operator-valued kernels. Moreover, we extend...