OBJECTIVES This study assessed the cost effectiveness of a three-year school-based pit and fissure dental sealant and fluoride mouthrinsing program in two nonfluoridated regions in Victoria, Australia. METHODS The analysis was based on a community intervention in five schools comparing an intervention group receiving the pit and fissure dental sealant, a weekly fluoride mouthrinsing, and an a...

PURPOSE To investigate the prognostic value of cavernoussinus invasion (CSI) in patients with nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT). PATIENTS AND METHODS Retrospective review of data from 1,087 patients with biopsy-proven, non-metastatic NPC. All patients were diagnosed using magnetic resonance imaging (MRI) scans and received IMRT as the primary ...

In the MINDACT trial, 4 risk categories (RC) by clinical (c) and genomic (g) risks were defined. cHigh/gLow patients (pts) with no adjuvant chemotherapy (CT), 8y-Distant Metastases Free Survival (DMFS) was 89.4 % [95% CI 86.2-91.5]. MP also identified a third subgroup of gUL pts (score 0.355 – 1.0, 15% in MINDACT), an excellent prognosis benefit from extended endocrine therapy (EET). We aimed t...

DMFs are spherical DNA-diacyllipid nanostructures formed by hydrophobic effects between lipid tails coupled to single-stranded DNAs. Such properties as high cellular permeability, low critical micelle concentration (CMC) and facile fabrication facilitate intracellular imaging and drug delivery. While the basic properties of NFs have been amply described and tested, few studies have characterize...

OBJECTIVES Claims have been made that the effectiveness of water fluoridation has reduced due to the widespread availability of other sources of fluoride. This study examines the differences in the oral health of children living in fluoridated and non-fluoridated areas of Canterbury and Wellington, New Zealand. DESIGN The data used in this cross-sectional study had been routinely collected in...

In a prospective longitudinal study, 1099 first grade children from Aiken, South Carolina, and 1086 children from Portland, Maine, were examined annually for 3 years. Caries prevalence and dmfs incidence were determined. The mean dmfs in Portland children was 2.9. In Aiken, white children had a mean dmfs of 8.4, and black children had a mean dmfs of 10.2. The mean 3-year primary tooth caries in...

PURPOSE A gap analysis survey of international practices for Active Substance Master Files (ASMFs)/Drug Master Files (DMFs) of human use was conducted as a project of the ASMF/DMF working group of the International Generic Drug Regulators Pilot (IGDRP) to identify similarities and differences among ASMF/DMF procedures of 10 IGDRP members and 2 observers. METHODS We conducted a questionnaire s...

BACKGROUND Smoking and the use of smokeless tobacco have a detrimental impact on general and oral health. The relationship to dental caries is however still unclear. As caries is a multi-factorial disease with clear life-style, socio-economic and socio-demographic gradients, the tobacco use may be a co-variable in this complex rather than a direct etiological factor. Our aim was to analyze the ...

A deep learning approach for the efficient electromagnetic analysis of an on-chip inductor with dummy metal fillings (DMFs) is proposed. By comparing different activation functions and loss functions, a neural network DMF modeling built using smooth maximum unit function log-cosh function. The parasitic capacitive effect DMFs quickly accurately extracted though this model, effective permittivit...

This study was undertaken to determine the caries prevalence and restorative needs of United States Air Force (USAF) family members ages 3-15. Examinations were performed on 1802 USAF children at five bases. Indexes recorded were: Decayed, Missing, Filled Surfaces (DMFS) for permanent teeth; decayed, filled surfaces (dfs) for primary teeth; and a Dental Restorative Treatment Need Index. Results...