Shenxiong glucose injection (SGI), a traditional Chinese medicine (TCM) preparation, has been widely used for the treatment of various cardiovascular and cerebrovascular diseases for many years. We assessed the potential influences of SGI on the activities of six CYP enzymes (CYP1A2, CYP2C11, CYP2C19, CYP2D4, CYP2E1, and CYP3A2) and on the pharmacokinetics of warfarin in rats. We compared plasm...

BACKGROUND The prevalence of multiple organ dysfunction syndrome (MODS) in horses with acute surgical gastrointestinal (GI) disease is unknown. Currently, there are no validated criteria to confirm MODS in adult horses. OBJECTIVES To develop criteria for a MODS score for horses with acute surgical colic (MODS SGI) and evaluate the association with 6-month survival. To compare the MODS SGI sco...

OBJECTIVE To investigate the antitumor effect of SGI-1776 on human ovarian cancer HO-8910 cells and its molecular mechanism. METHODS HO-8910 cells were cultured in vitro, and the proliferation inhibitory effects of SGI- 1776 were determined by MTT assay and colony formation assay. The effect of SGI-1776 on the distribution of cell cycle phase was observed by flow cytometry with propidium iodi...

We show that the Hartree-Fock-Bogoliubov (HFB) method is able to describe experimental values of alpha decay widths by including a residual nucleon-nucleon Surface Gaussian Interaction (SGI) within standard procedure used calculate nuclear mean field. call this Cluster HFB (CHFB) approach. In way we correct deficient asymptotic behaviour corresponding single-particle (sp) wave functions generat...

We started to implement SMP support for the OpenBSD/sgi port and selected the SGI Octane as the first target machine. We are now at the point where we have almost finished, except for the implementation of some non-critical features. SMP support is now operational on SGI Octane systems and the code has been merged into the OpenBSD tree.

The proviral integration site for moloney murine leukemia virus (Pim) kinases, consisting of Pim-1, Pim-2 and Pim-3, belongs to a family of serine/threonine kinases that are involved in controlling cell growth and differentiation. Pim kinases are emerging as important mediators of adipocyte differentiation. SGI-1776, an inhibitor of Pim kinases, is widely used to assess the physiological roles ...

Our previous studies have shown that when slices of the rat superior colliculus (SC) are exposed to a solution containing 10 microM bicuculline and a low concentration of Mg2+ (0.1 mM), most neurons in the intermediate gray layer (stratum griseum intermediale; SGI), wide-field vertical (WFV) cells in the optic layer (stratum opticum; SO), and a minor population of neurons in the superficial gra...

Introduction: Sensory Gating Inventory (SGI) measures behavioral aspects of Sensory Gating (SG). It is a filtering mechanism of brain that prevents irrelevant sensory inputs from entering into higher cortex information processing. It modifies sensitivity to sensory stimuli. Abnormal SG leads to overloading of information into cortex and brain dysfunction. Electrophysiological techniques cannot ...

Purpose: To investigate SGI-110 as a "chemosensitizer" in ovarian cancer and to assess its effects on tumor suppressor genes (TSG) and chemoresponsiveness-associated genes silenced byDNAmethylation in ovarian cancer. Experimental Design: Several ovarian cancer cell lines were used for in vitro and in vivo platinum resensitization studies. Changes in DNAmethylation and expression levels of TSG a...