problem of heterogeneity of 1gM arises in Waldenstr#{246}m macroglobulinemia, collagen diseases, and chronic liver diseases, for example, in which a variable proportion of the 1gM might be monomeric (6). Two problems can arise in these situations: if a single monoclonal fraction is present, one may ask whether it is monomeric or polymeric; a shift in electrophoretic mobility after reduction wil...

A patient developed immune hemolysis and thrombocytopenia while receiving quinidine. In vitro testing showed that antiquinidine antibodies of the lgG class were active against both cell lines. Complementand drug-dependent platelet lysis occurred with either the patient’s serum or his lgG fraction; there was no reaction with his 1gM fraction. Drug-dependent red cell antibodies were studied by an...

Introduction: Portulaca oleracea is a common plant used in South Indian culinary; recently there is increase in research publication on various biological activities of the medicinal herb. The safety of the medicinal herb well accounted by its widespread accepted use of natives yet scientific evaluation on the safety of the herb is not reported. Aim To scientifically evaluate the toxicity profi...

T HE COLD AGGLUTININ SYNDROME (C.A.S.) is characterized by high-titre cold agglutinins, a hemolytic anemia, Raynaud phenomena in the cold, various degrees of hemoglobinuria, and sometimes gangrene. Because of the hemolysis, the syndrome is most often classified as an autoimmune hemolytic anemia. However, treatment with ACTH, corticosteroids or splenectomy, most often used in this condition, has...

OBJECTIVE To determine the frequency of dyslipidemia in patients with lupus nephritis and its association with the degree of proteinuria. METHODS This cross-sectional analytic study included 65 patients who fulfilled the ACR (American College of Rheumatology) criteria for SLE and had renal involvement, presenting to the Division of Rheumatology, Fatima Memorial Hospital (FMH), and Lahore from...

Objective: Mesobuthus tumulus is the most lethal among all poisonous species of scorpion. Aristolochia indica is one of the plants which have long been used in traditional herbal medicine for the treatment of poisoning by animal bites. Hence the study was planned to evaluate the ethanolic extract of Aristolochia indica for the treatment of Mesobuthus tamulus envenoming. Materials and Methods: C...

Manual procedures have been developed for determination in human cerebrospinal fluid of the immunoglobulins lgG, IgA, and 1gM. An automated continuous-flow procedure for determination of lgG in human CSF is also described. The immunoglobulins are quantitated in both cases by immunoprecipitin reactions, with use of commercial antiserum. Values determined for the immunoglobulins by the manual met...

One hundred and sixty three cases of sporadic acute viral hepatitis were included in this study. Clinical diagnosis in all cases was supported by laboratory evidence of hepatocellular necrosis (AST/ALT levels 2.5 times the upper limit of normal). Sera collected in acute phase and stored at -20°C were analysed for various seromarkers of hepatitis using radioimmunoassay technique (Abbott Laborato...

CLINICAL CHEMISTRY, Vol. 23, No. 2, 1977 305 captoethanol was used per liter. We consider that this is due to the known tendency of mercaptoethanol to form aggregates with immunoglobulins, mainly IgG3 and 1gM (3-5). This observation was confirmed when we investigated the effect of two concentrations of mercaptoethanol (2.5 X i0 and 4.0 X 10 mol/liter) on the serum proteins, including immunoglob...

quantitative serum level measurements of gc , cp , c3 , igg , iga and 1gm were carried out on 102 patients with esophageal carcinoma following laryngectomy, in comparison with 66 healthy individuals as controls, in gonbad area, north east of iran. the procedure of radioinimuno-diffusion by standard m partigen plates was used for the measurements. a significant decrease was observed in gc level ...