نتایج جستجو برای: فاکتور cox2

تعداد نتایج: 14897  

Journal: :Human molecular genetics 2016
Alok Ghosh Anthony T Pratt Shivatheja Soma Sarah G Theriault Aaron T Griffin Prachi P Trivedi Vishal M Gohil

Biogenesis of cytochrome c oxidase (CcO), the terminal enzyme of the mitochondrial respiratory chain, is a complex process facilitated by several assembly factors. Pathogenic mutations were recently reported in one such assembly factor, COA6, and our previous work linked Coa6 function to mitochondrial copper metabolism and expression of Cox2, a copper-containing subunit of CcO. However, the pre...

Journal: :Hypertension 2009
Fara Sáez Virginia Reverte Francisco Salazar María T Castells María T Llinás F Javier Salazar

Several studies have proposed that cyclooxygenase-2 (COX2) is involved in the regulation of nephrogenesis and that an impaired nephrogenesis may induce the development of hypertension. This study was designed to test the hypothesis that the decrease of COX2 activity leads to a reduction in nephron number, an increase in arterial pressure, and age-dependent renal alterations that are greater in ...

Journal: :Human molecular genetics 2014
Myriam Bourens Aren Boulet Scot C Leary Antoni Barrientos

Cytochrome c oxidase (CIV) deficiency is one of the most common respiratory chain defects in patients presenting with mitochondrial encephalocardiomyopathies. CIV biogenesis is complicated by the dual genetic origin of its structural subunits, and assembly of a functional holoenzyme complex requires a large number of nucleus-encoded assembly factors. In general, the functions of these assembly ...

Journal: :Archives of pathology & laboratory medicine 2006
Rosaria Maddalena Ruggeri Salvatore Sciacchitano Enrica Vitarelli Francesco Trimarchi Gaetano Barresi Maria Trovato

CONTEXT Chemoresistance is due to the expression of multidrug-resistance proteins (MRPs). Cyclooxygenase 2 (COX2), a key enzyme in prostaglandins synthesis, upregulates MRP1. MRP1 is overexpressed in medullary thyroid carcinomas (MTCs), but it is not involved in resistance to doxorubicin and cisplatin, which are commonly used in MTC treatment. MRP2 is specifically involved in resistance to both...

Journal: :Hypertension 2006
Zhonghua Qi Hui Cai Jason D Morrow Matthew D Breyer

Accumulating evidence indicates cyclooxygenase (COX) 1 and COX2 differentially regulate cardiovascular and renal function. We have demonstrated previously in mice that COX2 inhibition enhances angiotensin II-induced hypertension, and COX1 inhibition attenuates the pressor effect of angiotensin II. To further elucidate the mechanism underlying the functional difference of COX1 versus COX2 inhibi...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2015
Elaine E Wirrig M Victoria Gomez Robert B Hinton Katherine E Yutzey

OBJECTIVE Calcific aortic valve disease (CAVD) is a significant cause of morbidity and mortality, which affects ≈1% of the US population and is characterized by calcific nodule formation and stenosis of the valve. Klotho-deficient mice were used to study the molecular mechanisms of CAVD as they develop robust aortic valve (AoV) calcification. Through microarray analysis of AoV tissues from klot...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
M Nakayama K Uchimura R L Zhu T Nagayama M E Rose R A Stetler P C Isakson J Chen S H Graham

The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is not known whether COX2 activity is pathogenic in brain. To study the role of COX2 activity in ischemic injury in brain, expression of COX2 mRNA and protein and the effect of treatment with a COX2 inhib...

2016
Junjie Hang Hai Hu Junjie Huang Ting Han Meng Zhuo Yangyang Zhou Lei Wang Yi Wang Feng Jiao Liwei Wang

Previous studies showed that celecoxib, a cyclooxygenase-2 (COX2) inhibitor, can inhibit angiogenesis and metastasis of pancreatic ductal adenocarcinoma (PDAC) via the suppression of specificity protein 1 (Sp1). In this study, we investigated the prognostic value of Sp1 and COX2 in 88 PDAC patients. Our study showed there was a positive correlation between Sp1 and COX2 expression (P=0.001) by u...

Journal: :The Journal of clinical investigation 2002
Zhonghua Qi Chuan-Ming Hao Robert I Langenbach Richard M Breyer Reyadh Redha Jason D Morrow Matthew D Breyer

Therapeutic use of cyclooxygenase-inhibiting (COX-inhibiting) nonsteroidal antiinflammatory drugs (NSAIDs) is often complicated by renal side effects including hypertension and edema. The present studies were undertaken to elucidate the roles of COX1 and COX2 in regulating blood pressure and renal function. COX2 inhibitors or gene knockout dramatically augment the pressor effect of angiotensin ...

2012
John Karavitis Laura M. Hix Yihui H. Shi Rachael F. Schultz Khashayarsha Khazaie Ming Zhang

BACKGROUND The targeting of the immune system through immunotherapies to prevent tumor tolerance and immune suppression are at the front lines of breast cancer treatment and research. Human and laboratory studies have attributed breast cancer progression and metastasis to secondary organs such as the bone, to a number of factors, including elevated levels of prostaglandin E2 (PGE2) and the enzy...

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