At the quarterly clinicopathological conference held at the Royal College of Physicians on 26 July 1979 Dr C C Booth (1) took the chair. He opened the conference by saying that it would take an unusual reverse form in which a pathologist, Dr I Doniach, would be invited to comment on the pathological findings and reconstruct the clinical history and that the true clinical history would be reveal...

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Acknowledgements I would like to extend my gratitude to my supervisor Sam Howison for his guidance and advice throughout the preparation and writing of this dissertation. I would also like to thank Christoph Reisinger for his advice whilst Dr Howison was away. Finally and most importantly I would like to thank my parents for their continued emotional and financial support, without which I would...

Sir, I was recently on call for nephrology, and something happened. I was rung by a first year junior doctor at 1 am, saying that a patient's 'MEWS score was 6'. The patient had had a renal transplant that day. A score of 6 is very high. It should trigger a rapid senior review, and possible intensive care re-ferral. Modified early warning score (MEWS) is an electronic early warning score based ...

BLOOD VESSEL DISEASES Blood vessels have a primary function of nourishing various organs and tissues of the body by supplying them with blood. Vascular diseases are manifested clinically through three mechanisms that are reflected through the diseased vessel (s) as 1. Progressive narrowing of the lumen associated with progressive ischemia of the relevant tissues. 2. Thrombosis associated with p...