INTRODUCTION Patients with acute-on-chronic liver failure show an aggravated hyperdynamic circulation. We evaluated, in a controlled manner, potential changes in systemic haemodynamics induced by the molecular adsorbent recirculating system (MARS) and the Prometheus system liver detoxification devices in a group of patients with acute-on-chronic liver failure. METHODS Eighteen patients (51.2 ...

This paper describes a debugger which uses the design artifacts of the Prometheus agent oriented software engineering methodology to alert the developer testing the system, that a specification has been violated. Detailed information is provided regarding the error which can help the developer in locating its source. Interaction protocols specified during design, are converted to executable Pet...

Agent Orientation is emerging as a dominant research area and also prevails as a new paradigm for constructing complex distributed system. Agents provide designers/developers with a way of structuring applications around autonomous, communicative elements. Thus, Agent Oriented Software Engineering (AOSE) is concerned with the use of agents in the development of complex distributed systems, espe...

Process mining is an established approach for analyzing and modeling complex business processes. In this paper we showcase ProMetheuS, a flexible and scalable suite for process mining natively designed for industrial applications. Moving from the experience of the ProM framework, the state-of-art process mining tool, ProMetheuS introduces three innovative designing elements. Firstly, ProMetheuS...

The following paper presents an overview of the Prometheus design system and its applications to gas turbine combustor design. Unlike a traditional “optimizer-centric” method, Prometheus aims to reduce both the level of workflow complexity and rework by taking a more “geometry-centric” approach to design optimization by shifting the control of script generation away from the optimization progra...

Firewalls are the most prevalent and important means of enforcing security policies inside networks and across organizational boundaries. However, effective and fault free firewall management in large and fast growing networks becomes increasingly more challenging. Firewall security policies are complex and their interaction with routing policies and applications further complicates policy conf...

This paper introduces a multi-agent system (MAS) approach using the detailed process provided by Prometheus methodology for the design of a moving robot application for the detection and following of humans. Our conjecture is that complex autonomous robotic systems have to be fully modeled in their initial design stages by means of agent-based technology. The application has been completely mod...