An immunomodulator PS-K was shown to diminish the cyclophosphamide (CY)-induced suppression of specific antitumor transplantation resistance in WKA rats immunized with X-irradiated KMT-17 tumor cells when PS-K was given before treatment of CY. In the immunochemotherapy of transplanted KMT-17 tumor in WKA rats by a combination of CY and PS-K, an enhanced therapeutic effect was also observed when...

An immunomodulator PS-K was shown to diminish the cyclophosphamide (CY)-induced suppression of specific antitumor transplantation resistance in WKA rats immunized with X-irradiated KMT-17 tumor cells when PS-K was given before treat ment of CY. In the immunochemotherapy of transplanted KMT17 tumor in WKA rats by a combination of CY and PS-K, an enhanced therapeutic effect was also observed when...

In this paper we first study the moduli spaces related to Calabi-Yau manifolds. We then apply the results to the following problem. Let C be a fixed Riemann surface with fixed finite number of points on it. Given a CY manifold with fixed topological type, we consider the set of all families of CY manifolds of the fixed topological type over C with degenerate fibres over the fixed points up to i...

A prospective randomized study was conducted comparing two conditioning regimens for the treatment of patients with chronic myeloid leukemia in chronic phase by marrow transplantation from HLA identical siblings. Sixty-nine patients received 60 mg/kg of cyclophosphamide on each of 2 successive days followed by 6 fractions of total body irradiation each of 2.0 Gy (CY-TBI), and 73 patients receiv...

Abstract Gestational trophoblastic tumors seriously endanger child productive needs and the health of women in childbearing age. Nanodrug-based therapy mediated by transporters provides a novel strategy for treatment tumors. Focusing on overexpression human equilibrative nucleoside transporter 1 (ENT1) membrane choriocarcinoma cells (JEG-3), cytarabine (Cy, substrate ENT1)-grafted liposomes (Cy...

Pretreatment of experimental animals with cyclophosphamide (CY) markedly potentiates the acquisition of T-cell-mediated immunity to an antigen given 1 to 4 days later. We have examined the primary induction of delayed-type hypersensitivity (DTH) and antibody to keyhole limpet hemocyanin (KLH) and DTH to 1-chloro-2,4-dinitrobenzene (DNCB) in 22 patients receiving CY for metastatic cancer, 12 wit...

1. The heterogeneity of cytochrome c obtained in the monomeric form from different organs of rat was studied. Disc electrophoresis on polyacrylamide gel ievealed the presence of four forms in heart muscle, liver, and kidney. In the kidney, the mean percentage distribution was Cy I 86.2 %, Cy II S.O%, Cy III 4.2%, and Cy IV 1.6%. 2. The rate at which radioactive iron (SYFe) is incorporated into ...

1. The heterogeneity of cytochrome c obtained in the monomeric form from different organs of rat was studied. Disc electrophoresis on polyacrylamide gel ievealed the presence of four forms in heart muscle, liver, and kidney. In the kidney, the mean percentage distribution was Cy I 86.2 %, Cy II S.O%, Cy III 4.2%, and Cy IV 1.6%. 2. The rate at which radioactive iron (SYFe) is incorporated into ...

From March 1988 to March 1991, 19 French bone marrow transplant (BMT) centers participated in a prospective randomized trial comparing two conditioning regimens for patients with chronic myeloid leukemia transplanted in first chronic phase with an HLA identical sibling donor. A total of 120 consecutive patients were randomized to receive either 120 mg/kg of cyclophosphamide followed by total bo...