Objective(s): Sepsis can result in severe organ injury by provoking inflammatory cascades and oxidative stress. Several studies are currently underway to find a drug with anti-inflammatory effects to prevent mortality and morbidity during sepsis. The present study was undertaken to assess the effects of metformin on oxidative stress and antioxidant status in sepsis induced by the Cecal Ligation...

We study under which conditions the domain of-terms (() and the equality theory of the-calculus () form the basis of a usable constraint logic programming language (CLP). The conditions are that the equality theory must contain axiom , and the formula language must depart from Horn clauses and accept universal quantiications and implications in goals. In short, CLP((,) must be close to Prolog. ...

Background: Cleft palate (CP) with or without cleft lip (CL/P) are the most common  craniofacial birth defects.  Cleft lip and palate (CLP) can affect children’s communication skills.  The present study aimed to evaluate the language production skills in regards to morphology and syntax (morphosyntactic) of children with CLP . Method: In current cross-sectional study, 58 Persian-language child...

The effects of hypertonic saline solution (HSS) have been shown in several animal models of ischemia and shock. Literature has shown potential benefits of HSS modulating inflammatory response after sepsis in an animal model. We studied the HSS effects in sepsis through cecal ligation and puncture (CLP) in Balb-C mice. Groups studied: 1- CLP without treatment (CLP-C); 2- CLP treated with normal ...

Purpose: To investigate the mechanism of resveratrol protection against sepsis-induced acute kidney injury in mice.
 Methods: A model was established mice by cecal ligation and puncture (CLP). Sixty healthy male ICR were randomly divided into sham operation (sham) group, (CLP) CLP + low-dose (20 mg/kg) treatment (CLP ResL) high-dose (40 ResH) group Klotho (0.01 Klotho) group. All administe...

context: sepsis is one of the major causes of death in intensive care units. oxidative stress and hyper-inflammation has been shown to be major cause of mortality and morbidity in septic cases. pomegranate is a fruit considered for its antioxidant and anti-inflammatory properties. aims: the aim of this study is to evaluate the effect of a standard pomegranate fruit liquid extract  (pomx), on mo...

Background: Sepsis is a systemic inflammatory disease in response to the pathogens that leads to vital organ failures the failure of vital organs. Appropriate animal models should be developed to measure the effectiveness of therapeutic methods. Cecal Ligation and Puncture (CLP) is the most widely used methods of creating the sepsis model. Some variables interfere in the creation of the CLP mod...