The unstimulated platelet surface contains a specific and saturable binding site for high molecular weight kininogen (HK) and low molecular weight kininogen (LK). Investigations were performed with purified heavy and light chains of HK to determine which portion(s) of the HK molecule binds to the platelet surface. Purified 64-Kd heavy chain of HK and 56-Kd light chain of HK, independently, inhi...

Hypergamy, Cross-Boundary Marriages, and Family Behavior We study the rise in marriages between residents of HK and China following the handover of HK to China in 1997. Cross-boundary marriages accounted for almost half the marriages registered in HK in 2006. Because of large differences in male income between China and HK, marriages of HK men with Mainland women outnumbered those of HK women w...

High molecular weight kininogen (HK) is a multifunctional plasma glycoprotein that occupies a critical position in pathways that link inflammation and coagulation. Excision of the vasoactive peptide bradykinin by plasma kallikrein results in kinin-free HK that consists of a 65-Kd N-terminal heavy chain (HK-HC) linked to the C-terminal 45-Kd light chain (HK-LC) by a disulfide bridge. HK-HC is an...

Substance P (SP) is a member of the tachykinin peptide family. Hemokinin-1 (HK-1) was recently identified as a new mammalian tachykinin peptide. SP and HK-1 consist of undecapeptides and share a common carboxyl-terminal (C-terminal), Phe-Xaa-Gly-Leu-Met-amide motif, and more varied amino-terminals (N-terminal). The function of SP in the pain system of the spinal cord has been examined in detail...

The original Hegselmann-Krause (HK) model consists of a set of~$n$ agents that are characterized by their opinion, number in~$[0, 1]$. Each agent, say agent~$i$, updates its opinion~$x_i$ taking the average opinion all neighbors, whose differs from~$x_i$ at most~$\epsilon$. There two types of~HK models: synchronous~HK and asynchronous~HK model. For synchronous model, update simultaneously each ...

Abstract The whole blood potassium concentration has shown the bimodal distribution in sheep, which has been classified into LK and HK types; HK allele is recessive to LK with a single gene inheritance. This polymorphism showed different behavior in different environment, which could be due to adaptation process. This research was conducted on the Zel and kermani breed research station, which...

Ferritin is a protein principally known for its role in iron storage. We have previously shown that ferritin can bind high-molecular-weight kininogen (HK). Upon proteolytic cleavage by the protease kallikrein, HK releases the proinflammatory peptide bradykinin (BK) and other biologically active products, such as two-chain high-molecular-weight kininogen, HKa. At inflammatory sites, HK is oxidiz...

Increased glucose utilization and hexokinase (HK)-II expression are adaptive features of lung cells exposed to hypoxia or hyperoxia. HK-II is the most regulated isoform of HK. Whether its overexpression could be protective against oxidative stress was explored in human lung epithelial-like (A549) cells. HK-II was overexpressed in A549 cells in a tetracycline-repressible retroviral vector system...

We developed a mouse monoclonal antibody (MoAb 115-21) to human high-molecular-weight kininogen (HK) that recognizes its prekallikrein binding site (residues 565 through 595 of HK). The corresponding synthesized 31-amino acid peptide (peptide IV) was recently shown to retain native HK's prekallikrein binding property. The same peptide bound factor XI also, although less avidly. Our MoAb recogni...