Comment. Both MEB disease and Walker-Warburg syndrome have underlying deficiencies in posttranslational glycosylation of -dystroglycan that lead to severe defects in organogenesis and neuronal migration. Brain and eye phenotypes in MEB disease and WalkerWarburg syndrome likely involve defective glycosylation in proteins other than -dystroglycan since chimeric mice deficient in -dystroglycan dev...

A new simple, rapid and sensitive reversed-phase liquid chromatographic method was developed and validated for the simultaneous determination of sulpiride (SUL) and mebeverine Hydrochloride (MEB) in the presence of their impurities and degradation products. The separation of these compounds was achieved within 6 min on a 250 mm, 4.6 mm i.d., 5 m particle size Waters®-C18 column using isocractic...

Muscle-eye-brain disease (MEB) and Walker Warburg Syndrome (WWS) belong to a spectrum of autosomal recessive diseases characterized by ocular dysgenesis, neuronal migration defects, and congenital muscular dystrophy. Until now, the pathophysiology of MEB/WWS has been attributed to alteration in dystroglycan post-translational modification. Here, we provide evidence that mutations in a gene codi...

BACKGROUND Muscle-eye-brain disease (MEB) is a rare autosomal recessive disorder characterized by congenital muscular dystrophy, structural eye abnormalities, and type II lissencephaly. Previous reports of brain abnormalities on magnetic resonance images (MRIs) in MEB have been in children older than 1 year. OBJECTIVE To describe serial antenatal and postnatal brain MRIs in a child with MEB. ...

National Academy of Sciences • National Academy of Engineering • Institute of Medicine • National Research Council Mental, emotional, and behavioral (MEB) disorders—which include depression, conduct disorder, and substance abuse—affect large numbers of young people. Studies indicate that MEB disorders are a major health threat and are as commonplace today among young people as a fractured limb-...

The study examined Symptom Validity Test (SVT) performance in a sample of military service members on active orders as a function of evaluation context. Service members were assessed in the context of either a pending disability evaluation (Medical Evaluation Board; MEB) or a non-MEB/clinical evaluation. Overall, 41.8% of the sample failed the Word Memory Test; however, significantly more indiv...

Mutual Exclusion Bootstrapping (MEB) was designed to overcome the problem of semantic drift suffered by iterative bootstrapping, where the meaning of extracted terms quickly drifts from the original seed terms (Curran et al., 2007). MEB works by extracting mutually exclusive classes in parallel which constrain each other. In this paper we explore the strengths and limitations of MEB by applying...

BACKGROUND Nutritional and topical antioxidants and immuno-modulant compounds play a key role in maintaining healthy skin. However, little is known about the combined effects antioxidant cosmeceuticals and nutricosmetics can have on the appearance of aging skin. OBJECTIVE The clinical trial was designed to study the combined effects on skin hydration, superficial lipids, elasticity, peroxidat...

The miniaturization boiling (micro-bubble emission boiling [MEB]) phenomenon, with a high heat removal capacity that contributes considerably to the cooling of the divertor of the nuclear fusion reactor, was discovered in the early 1980s. Extensive research on MEB has been performed since its discovery. However, the progress of the application has been delayed because the generation mechanism o...

Iterative bootstrapping techniques are commonly used to extract lexical semantic resources from raw text. Their major weakness is that, without costly human intervention, the extracted terms (often rapidly) drift from the meaning of the original seed terms. In this paper we proposeMutual Exclusion bootstrapping (MEB) in which multiple semantic classes compete for each extracted term. This signi...