Monoamine oxidase (EC 1.4.3.4; MAO) is the primary enzyme responsible for the intraneuronal degradation of biogenic amines in the central nervous system. An understanding of the physiological significance of the functional and regulatory differences between the two forms of the enzyme, MAOs A and B, would be facilitated by the availability of antibodies specific for the two forms of the enzyme....

Monoamine oxidase (MAO) is a key enzyme responsible for the degradation of serotonin, norepinephrine, dopamine, and phenylethylamine. It is an outer membrane mitochondrial enzyme existing in two isoforms, A and B. We have recently generated 14 site-directed mutants of human MAO A and B, and we found that four key amino acids, Lys-305, Trp-397, Tyr-407, and Tyr-444, in MAO A and their correspond...

This study presents methods for treating a kind of nanoclay and investigates the effects of methylaluminoxane (MAO) exposure time and or dodecylamine (DDA) reflux time on in-situ polymerization of ethylene in the presence of nanoclay and examines the morphology and properties of the prepared polyethylene/clay nanocomposites. The results revealed that by increasing MAO exposure time productivity...

The anticonvulsant activity of inhibitors of monoamine oxidase (MAO) was reported early after the development of irreversible MAO inhibitors such as tranylcypromine, but was never clinically used because of the adverse effects of these compounds. The more recently developed reversible MAO inhibitors with selectivity for either the MAO-A or MAO-B isoenzyme forms have not been studied extensively...

Monoamine oxidase (MAO) exists as two isoenzymes and plays a central role in the metabolism of monoamine neurotransmitters. In this study we compared the neurochemical phenotypes of previously described subjects with genetically determined selective lack of MAO-A or a lack of both MAO-A and MAO-B with those of two subjects with a previously described X chromosome microdeletion in whom we now de...

Introduction: Stress inhibits the development of tolerance to morphine analgesia via activating Hypothalamic- Pituitary-Adrenal (HPA) axis. Modified catecholamine systems have been reported following morphine tolerance development. In the current study we tried to evaluate changes in the gene expression levels for MAO-A, MAO-B, COMT and thyrosine hydroxylase (TyH) enzymes following chronic p...

In the mechanical, automobile, aerospace, and construction industries, Ti steel are mostly commercial materials be used. But poor hardness, wear, corrosion resistance limit their applications. this study, we presented a composite material that consists of thermal-sprayed titanium (Ti) layer on AISI 1020 steel. Then added different concentrations c-BN to electrolyte in MAO process enhance wear r...

Thirty-seven parents of probands with low platelet monoamine oxidase (MAO) activity levels and 38 parents of high MAO probands were examined for MAO activity, past and present psychopathology, and reported psychopathology in other relatives. Results showed generally positive and significant correlations between parents' and children's MAO levels, significantly greater rates of "high MAO related...

Monoamine oxidase (MAO), a mitochondrial flavine containing enzyme, exists in two isoenzymes, MAO-A and MAO-B. Platelets contain MAO-B subtype, proposed to be a biomarker for different personality characteristics and vulnerability for substance abuse. The most common polymorphism of MAO-B gene, a single base change (A or G) occurs in intron 13. It has been proposed to be a functional polymorphi...

Monoamine oxidase (MAO) oxidatively deaminates vasoactive and biogenic amines and exists in two distinct forms (A and B), coded for by separate genes, which exhibit distinct substrate specificities and inhibitor sensitivities. Using specific primers for MAO-A and MAO-B mRNA in a reverse transcription-polymerase chain reaction (RT-PCR) on RNA from human liver, the predicted products for both enz...