GS 4071 is a potent carbocyclic transition-state analog inhibitor of influenza virus neuraminidase with activity against both influenza A and B viruses in vitro. GS 4116, the guanidino analog of GS 4071, is a 10-fold more potent inhibitor of influenza virus replication in tissue culture than GS 4071. In this study we determined the oral bioavailabilities of GS 4071, GS 4116, and their respectiv...

INTRODUCTION We assessed the correlation between the apparent diffusion coefficient (ADC) and pathological Gleason score (GS) of prostate cancer patients. METHODS A total of 125 patients who underwent multiparametric magnetic resonance imaging before radical prostatectomy for prostate cancer were included in this study. ADC values were compared with different GS. We used receiver operating ch...

The Bacillus subtilis GlnR repressor controls gene expression in response to nitrogen availability. Because all GlnR-regulated genes are expressed constitutively in mutants lacking glutamine synthetase (GS), GS is required for repression by GlnR. Feedback-inhibited GS (FBI-GS) was shown to activate GlnR DNA binding with an in vitro electophoretic mobility shift assay (EMSA). The activation of G...

introduction: in the current study, we compared the h-indices of web of science (wos), scopus, and gs of the iranian nuclear medicine scientists methods: full time members of two major nuclear medicine research centers of iran with more than 5 year of experience (nuclear medicine research center of mashhad university of medical sciences, and research institute for nuclear medicine of tehran uni...

introduction: in the current study, we compared the h-indices of web of science (wos), scopus, and gs of the iranian nuclear medicine scientists methods: full time members of two major nuclear medicine research centers of iran with more than 5 year of experience (nuclear medicine research center of mashhad university of medical sciences, and research institute for nuclear medicine of tehran uni...

Introduction: In the current study, we compared the h-indices of Web of Science (WOS), SCOPUS, and GS of the Iranian nuclear medicine scientists Methods: Full time members of two major nuclear medicine research centers of Iran with more than 5 year of experience (Nuclear Medicine Research Center of Mashhad University of Medical Sciences, and Research Institute for Nuclear Medicine of Tehran Un...

Brassica sprouts contain abundant phytochemicals, especially glucosinolates (GSs). Various methods have been used to enhance GS content in sprouts. However, the molecular basis of GS metabolism in sprouts remains an open question. Here we employed RNA-seq analysis to compare the transcriptomes of high-GS (JL-08) and low-GS (JL-09) Brassica alboglabra sprouts. Paired-end Illumina RNA-seq reads w...

Maize (Zea mays L.) kernel pedicels, including vascular tissues, pedicel parenchyma, placento-chalazal tissue, and the surrounding pericarp, contained two forms of glutamine synthetase (EC 6.3.1.2), separable by anion exchange chromatography under mildly acidic conditions. The earlier-eluting activity (GS(p1)), but not the later-eluting activity (GS(p2)), was chromatographically distinct from t...

GS-9131 is a phosphonoamidate prodrug of the novel ribose-modified phosphonate nucleotide analog GS-9148 that demonstrates potent anti-human immunodeficiency virus type 1 (HIV-1) activity and an excellent resistance profile in vitro. Prodrug moieties were optimized for the efficient delivery of GS-9148 and its active diphosphate (DP) metabolite to lymphoid cells following oral administration. T...