Warfarin therapy is used in lupus anticoagulant patients with thrombosis and yet the prothrombin time (PT)/international normalized ratio (INR) in these patients can sometimes be falsely elevated. Both a PT-based factor II (FII) assay and a chromogenic, enzymatic factor X (CFX) assay have been used for monitoring when the INR may be artifactual. This study compared FII and CFX assays in lupus a...

Structural and bonding patterns arising from the incorporation of fluorine atoms in a graphene-like network relevant to the deposition of carbon fluoride (CFx) films were addressed by first-principles calculations. We find that large N-member (N=8 – 12) rings, defects by sheet branching, and defects associated with bond rotation pertain to CFx. The cohesive energy gains associated with these pa...

Background. ß-lactam antibiotics that are excreted into the intestine can damage the microflora, which can lead to serious infections such as Clostridium difficile (C. diff ). SYN-004 is a potent ß-lactamase formulated for oral use with intravenous (IV) antibiotics to degrade antibiotics in the intestine. Methods. SYN-004, formerly called P3A, was developed and evaluated by Ipsat Therapies, Hel...

In the present study, the antioxidant capacity of vitamin C was examined in the liver and the kidney tissues of mice with or without ciprofloxacin (CFX) treatment. The antioxidant capacity of the vitamin was evaluated in terms of lipid hydroperoxides (LOOH) and thiobarbituric acid reactive substances (TBARs). The experimental design was 15 days of water (control and CFX groups) or vitamin C (vi...

Preclinical Research The aim of this study was to determine the antiallodynic effect of acute administration of the β-lactam antimicrobials, ceftriaxone (CFX) and clavulanic acid (CLAV), for the control of established pain on a model of neuropathic pain (NP). We also investigated the involvement of dopaminergic and opioidergic pathways as well as alterations in serum concentrations of TNF-α in ...

Coronary spasm can occur in the presence or absence of coronary artery disease. We therefore determined the effect of preexisting coronary stenosis on the incidence of ventricular fibrillation during reperfusion after circumflex artery (CFX) occlusion. Twenty dogs underwent a 30-minute open-chest CFX occlusion. During reperfusion, CFX blood flow was restricted by a partial occluder. In dogs tha...

For the ANSYS CFD codes CFX and Fluent coupling links to several 1D codes exist allowing for a wide range of multi-physics applications. As an example, a flexible coupling infrastructure in terms of supported multiphysics coupling conditions between ANSYS CFX and LMS AMESim is outlined. Examples of the wide range of coupling solutions of ANSYS CFD (CFX and Fluent) and coupled 1D-3D applications...