Purpose Stereotactic radiosurgery (SRS) in combination with immunotherapy (IMT) or targeted therapy is increasingly being used in the setting of melanoma brain metastases (MBMs). The synergistic properties of combination therapy are not well understood. We compared the distant intracranial failure rates of intact MBMs treated with SRS, SRS + IMT, and SRS + targeted therapy. Methods and materi...

STUDY DESIGN A retrospective analysis. OBJECTIVE The aim of our study was to compare the normality, concurrent validity, internal consistency, responsiveness, and dimensionality of an item response theory-derived seven-question instrument (SRS-7), against the Scoliosis Research Society-22r (SRS-22r) questionnaire in operatively treated patients with adult spinal deformity (ASD). SUMMARY OF ...

BACKGROUND AND AIM: Proper scientific reporting is necessary to ensure correct interpretation of study results by readers. Systematic reviews (SRs) are of critical importance in evidence-based dentistry. This study assessed the reporting quality of published dental SRs in Iran.METHODS: The PubMed and ISI electronic databases were searched to collect published Iranian dental SRs up to the end of...

CONTEXT Silver-Russell syndrome (SRS) is a genetically heterogeneous syndrome characterized by low birth weight, severe short stature, and variable dysmorphic features. GH treatment is a registered growth-promoting therapy for short children born small for gestational age, including SRS, but there are limited data on the GH response in SRS children and on differences in response among the (epi)...

BACKGROUND Systematic reviews (SRs) are considered an important tool for decision-making. There has been no recent comprehensive identification or description of child-relevant SRs. A description of existing child-relevant SRs would help to identify the extent of available child-relevant evidence available in SRs and gaps in the evidence base where SRs are required. The objective of this study ...

OBJECTIVES To identify all systematic reviews (SRs) published in the domain of oral health research and describe them in terms of their epidemiological and descriptive characteristics. DESIGN Cross sectional, descriptive study. METHODS An electronic search of seven databases was performed from inception through May 2012; bibliographies of relevant publications were also reviewed. Studies we...

introduction: it is recommended that the physician apply at least a semi-quantitative segmental scoring system in myocardial perfusion spect.  we aimed to assess the agreement between automated semi-quantitative analysis using qps (quantitative perfusion spect) software and visual approach for calculation of summed stress  score (sss), summed rest score (srs) and summed difference score (sds). ...

We compared breeding bird populations on and off of the Savannah River Site (SRS), South Carolina, to determine whether management practices on SRS have affected abundance and composition of the resident avifauna. We assessed relative abundance by comparing Breeding Bird Survey (BBS) data from six routes off SRS with three surrogate routes generated using point-count data from four research pro...

STUDY DESIGN Comparison of the Scoliosis Research Society-22 (SRS-22) questionnaire with a 7-item Rasch-derived questionnaire (SRS-7). OBJECTIVE To compare the construct and discriminant validity, internal consistency, responsiveness, and dimensionality of SRS-7 against SRS-22 in operatively treated children with adolescent idiopathic scoliosis. SUMMARY OF BACKGROUND DATA SRS-22 has not bee...

OBJECTIVE Neurofibromatosis type 2 (NF2) is an autosomal dominant disease characterized by bilateral vestibular schwannomas (VSs). NF2-associated VSs (NF2-VSs) are routinely treated with microsurgery; however, stereotactic radiosurgery (SRS) has emerged as an effective alternative in recent decades. To elucidate the role of SRS in NF2-VSs, a systematic review of the literature was conducted to ...