Poly(ethylene glycol) (PEG) is increasingly used in clinical and experimental medicine. However, quantification of PEG and PEGylated small molecules remains laborious and unsatisfactory. In this report, we stably expressed a functional anti-PEG antibody on the surface of BALB 3T3 cells (3T3/alphaPEG cells) to develop a competitive enzyme-linked immunosorbent assay (ELISA) for PEG quantification...

Abstract In this work, two catalysts based on polyethylene glycol (PEG) containing sulfonic acid group and the −COOH of citric (CA) were synthesized. Characterization −SO 3 H functionalized PEG has been carried out using FT–IR. The acidity PEG–SO PEG–CA explored to investigate their catalytic efficiency towards eco-friendly production methyl salicylate via esterification salicylic methanol as a...

In the present work, docetaxel (DTX) and retinoic acid (RA) co-loaded micelles were developed for synergistic prostate cancer therapy. PEG-RA RA-PEG-RA synthesized subsequently used loading of DTX RA. The as prepared DTX/RA@RA-PEG-RA exhibit smaller size higher drug capacity compared to DTX/RA@PEG-RA micelles. in vitro release study shows that similar behaviours which exhibits fast RA sustained...

PURPOSE In a retrospective study, we evaluated the complications in using the motility peg system (nonsleeved and sleeved) for hydroxyapatite orbital implants in an anophthalmic socket. METHODS Drilling for motility peg placement was performed in 265 patients with hydroxyapatite implantation: nonsleeved peg system (n = 191), sleeved peg system (n = 74). A statistical analysis was performed us...

AIM To evaluate the complications associated with pegging of porous hydroxyapatite orbital implants. METHODS Complications associated with pegging were retrospectively reviewed from the charts of 100 of 133 patients with hydroxyapatite implantation from 1993 to 2000. RESULTS 48 (48%) of the 100 hydroxyapatite implanted patients who had undergone pegging were found to have problems with thei...

avoid from catch by the reticuloendothelial system (RES). It has been clarified that the prolongation of liposome circulation in the blood and passive targeting to the tumor was achieved by PEG modification of the liposomal surface. In terms of their physicochemical properties by PEG modification, many studies have examined the interaction between the prolonged circulation time of liposomes and...

BACKGROUND PEG-based laxatives are considered today the gold standard for the treatment of constipation in children. PEG formulations differ in terms of composition of inactive ingredients which may have an impact on acceptance, compliance and adherence to treatment. We therefore compared the efficacy, tolerability, acceptance and compliance of a new PEG-only formulation compared to a reference...

Polyethylene glycol (PEG) inhibited aggregation during refolding of bovine carbonic anhydrase B (CAB) through the formation of a nonassociating PEG-intermediate complex. Stoichiometric concentrations of PEG were required for complete recovery of active protein during refolding at aggregating conditions. For example, a PEG (Mr = 3350) to CAB molar ratio ([PEG]/[CAB]) of 2 was sufficient to inhib...

Methoxypolyethylene glycols of 1900 daltons (PEG-1900) or 5000 daltons (PEG-5000) were covalently attached to bovine liver catalase using 2,4,6-trichloro-s-triazine as the coupling agent. Rabbits were immunized by the intravenous and intramuscular routes with catalase modified by covalent attachment of PEG-1900 to 43% of the amino groups (PEG-1900-catalase). The intravenous antiserum did not yi...

Sphingopyxis terrae, and Sphingopyxis macrogoltabida strains 103 and 203, can degrade polyethylene glycols (PEGs). They differ in the following respects: (i) different substrate specificities (chain length) of assimilable PEG, (ii) PEG-inducible or constitutive PEG-degradative proteins, and (iii) symbiotic or axenic degradation of PEG. S. terrae was able to incorporate PEG 6000, but strain 103 ...