Cathepsins, a superfamily of hydrolytic enzymes produced and enclosed within lysosomes, function in immune response in vertebrates; however, their function within the innate immune system of invertebrates remains largely unknown. Therefore, we investigated the immune functionality of cathepsin A (catA) in Chinese mitten crab (Eriocheir sinensis), a commercially important and disease vulnerable ...

We show how to construct a one-pass optimizing transformation by fusing a non-optimizing transformation with an optimization pass. We state the transformation in build form and the optimization pass in cata form, i.e., as a catamorphism; and we use cata/build fusion to combine them. We illustrate the method by fusing Plotkin’s call-by-value and call-by-name CPS transformations with a reduction-...

Possessing a small size and C3-symmetrical rigid backbone, a coronene derivative was synthesized from β-cyclodextrins and hexa-cata-hexabenzocoronene, and then a water-soluble and biocompatible nanographene/polysaccharide supramolecular assembly was successfully fabricated through noncovalent interactions between adamantly grafted hyaluronic acids and β-cyclodextrin-modified hexa-cata-hexabenzo...

A large fraction (30 of 62) of the cata-condensed polycyclic benzenoid aromatic hydrocarbons with one to six rings have nonplanar pi carbon atom frameworks, with the minimum angle of nonplanarity approximately 30°. In addition to 17 pairs of enantiomers, four of the nonplanar cata-condensed benzenoids with six rings are redicted to be capable of existing as pairs of twisted diastereoisomers. Ma...

Este estudio compara dos métodos descriptivos basados ​​en las percepciones de los consumidores para conocer el perfil sensorial infusiones muña. Las personas participantes evaluaron cinco bebidas muña utilizando la metodología flash (Flash profile-FP) (n=20) y preguntas CATA (marque todo lo que corresponda o Check-All-That-Apply–CATA, siglas en inglés) (n=105). Para análisis datos, se utilizó ...

GS-7340 and GS-9131 {9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-propyl]adenine and 9-(R)-4'-(R)-[[[(S)-1-[(ethoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]-2'-fluoro-1'-furanyladenine, respectively} are novel alkylalaninyl phenyl ester prodrugs of tenofovir {9-R-[(2-phosphonomethoxy)propyl]adenine} (TFV) and a cyclic nucleotide analog, GS-9148 (phosph...

BACKGROUND Tenofovir alafenamide (TAF) is a novel investigational prodrug of tenofovir (TFV) that permits enhanced delivery of TFV into peripheral blood mononuclear cells (PBMCs) and lymphatic tissues. A critical step in the intracellular metabolic activation of TAF is mediated by the lysosomal protease cathepsin A (CatA). Here, we investigated CatA levels together with intracellular metabolism...

Background: A sequence of time-dependent changes can affect the brainchr('39')s functional capacity. Aims: This study aimed at investigating the effects of forced aerobic exercise (FAE) versus the rosemary extract (RE) on the learning abilities and oxidative stress modulation in rats. Methods: Young and old rats received daily FAE and RE for 3 months. Using the passive avoidance (PA) test, we...

We show how to construct a one-pass optimizing transformation by fusing a non-optimizing transformation with an optimization pass. We state the transformation in build form and the optimization pass in cata form, i.e., as a catamorphism; and we use cata/build fusion to combine them. We illustrate the method by fusing Plotkin’s call-by-value and call-by-name CPS transformations with a reduction-...

The self-CATA test proposed in this study allows consumers an opportunity to supplement the CATA terms with additional vocabulary from a previously generated standard list. Considering that some attributes listed on are frequently unselected by because most of them were provided previous sensory descriptive panel, even instrumental or texture parameters, consensus list obtain complete product c...