Objective: This study aimed to predict the effect of SNPs CYP2C9 s on metabolic activity S-warfarin in body.
 Methods: Molecular modeling was performed obtain and molecular docking S-warfarin.
 Results: The results showed that wild-type had strongest binding affinity (∆G: -9.76 kcal/mol), indicating best compared CYP2C9. There a decrease hydrogen bond formation an increase distance be...

Cytochrome P450 2C9 (CYP2C9) is the major enzyme involved in the metabolism of S-warfarin, an oral anticoagulant drug. Genetic polymorphisms of CYP2C9 gene have been reported and may play significant roles in pharmacogenomics. To date, over 5 CYP2C9 allelic variants have been reported. The most common allelic variants identified include CYP2C9*2 and CYP2C9*3. We conducted an investigation to de...

CYP2C9 is an important member of the cytochrome P450 enzyme superfamily with some 12 CYP2C9 alleles (*1-*12) being previously reported. Recently, we identified a new CYP2C9 allele with a Leu90Pro mutation in a Chinese poor metabolizer of lornoxicam [Si D, Guo Y, Zhang Y, Yang L, Zhou H, and Zhong D (2004) Pharmacogenetics 14:465-469]. The new allele, designated CYP2C9*13, was found to occur in ...

CYP2C9 is a polymorphic gene for which there are four known allelic variants; CYP2C9*1, CYP2C9*2, CYP2C9*3, and CYP2C9*4. In the present study, DNA from 140 European Americans and 120 African Americans was examined by single-strand conformational polymorphism and restriction fragment length polymorphism analyses, resulting in the identification of a new CYP2C9 variant, CYP2C9*5. This variant is...

The aim of the study: to establish frequencies polymorphisms in VKORC1, CYP2C9 and CYP4F2 genes among residents Zaporizhzhia region. Materials methods. A total 150 persons (62 male, 88 female) with a median age 46 years (26; 58) undergoing preventive examination at Medical Educational Scientific Center “University Clinic” State University (ZSMU). CYP2C9, CYP4F2, VKORC1 atrial fibrillation patie...

CYP2C9 was recently resequenced in 150 Asian subjects from Singapore. Several new coding variants were reported, and these variants are now named CYP2C9*14 (R125H), CYP2C9*15 (S162X), CYP2C9*16 (T299A), CYP2C9*17 (P382S), CYP2C9*18 (D397A), and CYP2C9*19 (Q454H). The CYP2C9*18 variant also contained an I359L change previously associated with the CYP2C9*3 allele. In this study, we assessed the f...

The requirement of varying doses of warfarin for different individuals can be explained by environmental and genetic factors. We evaluated the frequency of vitamin K epoxide reductase complex subunit 1 (VKORC1) and cytochrome P450 2C9 (CYP2C9) variants together with patientdemographic characteristics and investigated their association with warfarin dose requirement with the ob...

The present study was aimed to investigate the role of plasma glucose concentration as a phenotypic marker and to study the frequency distribution of CYP2C9 genetic variants in Gujarat state diabetic population. One hundred and nine unrelated diabetes mellitus patients treated with sulfonylureas were genotyped for CYP2C9*2 and CYP2C9*3 alleles. Their pre- and posttreatment postprandial blood gl...

BACKGROUND CYP2C9 is one of the major drug metabolizing enzymes for many drugs including warfarin, NSAIDs and losartan. It is polymorphic in many populations. Data on the distribution of CYP2C9 and the implication of CYP2C9 polymorphism in the Malaysian population is lacking. Our objectives were therefore to investigate the prevalence of CYP2C9 variants among unrelated healthy volunteers of Mal...

The aim of the present study is to assess and compare the frequencies of the cytochrome P450 CYP2C9 variations in the Baluch ethnic group (n=110) with other ethnic groups. The allele frequencies of CYP2C9*1, CYP2C9*2 and CYP2C9*3 were 80.90%, 11.82% and 7.27%, respectively. 70.90%, 11.82%, 8.18%, 4.55%, 2.73% and 1.82% of subjects were with CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CY...