Fragile X syndrome is the most frequent form of inherited mental retardation and is associated with a fragile site at Xq27.3. We identified human YAC clones that span fragile X site-induced translocation breakpoints coincident with the fragile X site. A gene (FMR-1) was identified within a four cosmid contig of YAC DNA that expresses a 4.8 kb message in human brain. Within a 7.4 kb EcoRI genomi...

BACKGROUND Mitral valve (MV) enlargement is a compensatory mechanism capable of preventing functional mitral regurgitation (FMR) in dilated ventricles. Total leaflet area and its relation with closure area measured by 3-dimensional (3D) echocardiography have been related to FMR. Whether these parameters can be assessed with other imaging modalities is not known. Our objectives are to compare ca...

OBJECTIVE Functional (or secondary) mitral regurgitation (FMR) is associated with greater morbidity and worse outcomes in patients with congestive heart failure (CHF) and cardiomyopathy. The Carillon® Mitral Contour System® is a coronary sinus-based percutaneous therapy to reduce FMR. We evaluated the safety and efficacy of a modified version of the Carillon device in the treatment of patients ...

Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25-90% of the radioactiv...

[1] Ferromagnetic resonance spectroscopy (FMR) can be used to measure the effective magnetic field within a sample, including the contributions of both magnetic anisotropy and magnetostatic interactions. One particular use is in the detection of magnetite produced by magnetotactic bacteria. These bacteria produce single-domain particles with narrow size and shape distributions that are often el...

We previously reported the isolation of a gene (FMR-1) expressed in brain at the fragile X locus. One exon of this gene lies within an EcoRI fragment that exhibits length variation in fragile X patients. This exon also contains the CGG repeat within the CpG island hypermethylated in fragile X patients. To study the involvement of the FMR-1 gene in the fragile X syndrome, its expression was stud...

Fragile X mental retardation protein (FMRP) is a neuronal translational repressor and has been implicated in learning, memory, and cognition. However, the role of Bacopa monnieri extract (CDRI-08) in enhancing cognitive abilities in hypoxia-induced memory impairment via Fmr-1 gene expression is not known. Here, we have studied effects of CDRI-08 on the expression of Fmr-1 gene in the hippocampu...

Immimofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation stu...

Introduction Functional mitral regurgitation (FMR) is a ventricular disease characterized by mitral valve insufficiency in the absence of structural abnormalities of the valve leaflets or sub-valvular apparatus.1 It commonly provokes heart failure and frequently confers an increase in patient mortality and morbidity. Medical therapy has a limited role for management of FMR. When treated, FMR is...

OBJECTIVE From a dental care perspective, we analyze whether the prevention of approximal caries by fluoride varnish treatment (FVT) or by fluoride mouth rinsing (FMR) could contain costs in an extended period of follow-up after the end of school-based prevention programs. MATERIAL AND METHODS It is assumed in a model that, after 3 years of prevention with either FVT or FMR according to publi...