نتایج جستجو برای: ژن homer 1a
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Transient receptor potential (TRP) channels are nonselective cation channels, several of which are expressed in striated muscle. Because the scaffolding protein Homer 1 has been implicated in TRP channel regulation, we hypothesized that Homer proteins play a significant role in skeletal muscle function. Mice lacking Homer 1 exhibited a myopathy characterized by decreased muscle fiber cross-sect...
Group I metabotropic glutamate receptors (mGluR1 and 5) couple to intracellular calcium pools by a family of proteins, termed Homer, that cross-link the receptor to inositol trisphosphate receptors. mGluRs also couple to membrane ion channels via G-proteins. The role of Homer proteins in channel modulation was investigated by expressing mGluRs and various forms of Homer in rat superior cervical...
Normal aging is associated with impairments in cognition, especially learning and memory. However, major individual differences are known to exist. Using the classical Morris Water Maze (MWM) task, we discriminated a population of 24-months old Long Evans aged rats in two groups--memory-impaired (AI) and memory-unimpaired (AU) in comparison with 6-months old adult animals. AI rats presented def...
Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene evolved bimodal expression of constitutive (Homer 1b and c) and immediate early gene (IEG) products (Homer 1a and Ania 3). The IEG forms compete functionally with the constitutive Homer proteins. The comp...
هدف: کبد چرب غیر الکلی طیفی از حالات بالینی – آسیب شناختی است که با رسوب قطرات چربی در کبد بیمارانی که سابقه مصرف الکل ندارند ، مشخص می شود . هیپرمتیلاسیون dna در نواحی پروموتر ژن ها نقش مهمی در کاهش بیان ژن های دخیل در بیماری کبد چرب غیر الکلی دارد . هدف از این مطالعه بررسی متیلاسیون پروموتر ژن های gstt1 ، gstp1 ، apoe ، cpt-1a ، mmp-9 و ctla-4 در بیماران مبتلا به کبد چرب غیر الکلی در جنوب شرق...
At hippocampal excitatory synapses, endocannabinoids (eCBs) mediate two forms of retrograde synaptic inhibition that are induced by postsynaptic depolarization or activation of metabotropic glutamate receptors (mGluRs). The homer family of molecular scaffolds provides spatial organization to regulate postsynaptic signaling cascades, including those activated by mGluRs. Expression of the homer 1...
سابفه و هدف: مواجهه حاد با نیکل باعث تغییر برنامه بیان ژن سلول های طبیعی گردیده و الگوی بیان ژن مشابه با سرطان های ناشی از نیکل را القاء می کند. هدف از این مقاله، بررسی مکانیسم های مختلف سرطانزایی نیکل می باشد. مواد و روش‌ها: مرور سیستماتیک در سایت های PubMed و Google scholar بر قدرت سرطان زایی ترکیبات نیکل در مدل های حیوانی و سلول های جوندگان در شرایط برون تنی صورت گرفت. نتایج: شواهد منتشر شده...
Glaucoma is a multifactorial progressive ocular pathology, clinically presenting with damage to the retina and optic nerve, ultimately leading to blindness. Retinal ganglion cell loss in glaucoma ultimately results in vision loss. Vesl/Homer proteins are scaffolding proteins that are critical for maintaining synaptic integrity by clustering, organizing and functionally regulating synaptic prote...
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