the determination of the ultimate pit limit (upl) is the first step in the open pit mine planning process. in this stage that parts of the mineral deposit that are economic to mine are determined. there are several mathematical, heuristic and meta-heuristic algorithms to determine upl. the optimization criterion in these algorithms is maximization of the total profit whilst satisfying the...

one of the main concerns of the mining industry is to determine ultimate pit limits. final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. the size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surfac...

background: sacral pit is a shallow or deep dimple in the lower sacral region, with a reported prevalence of 3-5% among newborns. the aim of the present study was to investigate spinal cord abnormalities in newborns with sacral pit via ultrasound examinations. methods: in this descriptive study, 3071 infants born at 34-42 weeks of gestation were studied in hospitals affiliated to islamic azad u...

OBJECTIVE Elevated serum phosphate has emerged as a major risk factor for vascular calcification. The sodium-dependent phosphate cotransporter, PiT-1, was previously shown to be required for phosphate-induced osteogenic differentiation and calcification of cultured human vascular smooth muscle cells (VSMCs), but its importance in vascular calcification in vivo and the potential role of its homo...

Although alternative splicing has been shown to give rise to isoforms of a number of transcription factors, such isoforms have not previously been detected for the POU homeodomain protein Pit-1. Screening of a rat pituitary GH3 cell cDNA expression library yielded a clone, termed pCMVPit-1a, encoding a 35.8 kD protein (Pit-1a) containing a 26 amino acid insert in the Pit-1 trans-activation doma...

Recent studies have suggested that species-specific pit properties such as pit membrane thickness, pit membrane porosity, torus-to-aperture diameter ratio and pit chamber depth influence xylem vulnerability to cavitation. Despite the indisputable importance of using mean pit characteristics, considerable variability in pit structure within a single species or even within a single pit field shou...

One of the main concerns of the mining industry is to determine ultimate pit limits. Final pit is a collection of blocks, which can be removed with maximum profit while following restrictions on the slope of the mine’s walls. The size, location and final shape of an open-pit are very important in designing the location of waste dumps, stockpiles, processing plants, access roads and other surfac...

Pavlovian conditioned stimuli can influence instrumental responding, an effect called Pavlovian-instrumental transfer (PIT). During the last decade, PIT has been subdivided into two types: specific PIT and general PIT, each having its own neural substrates. Specific PIT happens when a conditioned stimulus (CS) associated with a reward enhances an instrumental response directed to the same rewar...

Sungun Copper Mine is located in an area with a high level of seismic hazard. Most recently, the Ahar-Varzeqan earthquake with a magnitude of 6.2 on Richter scale occurred on August 11, 2012; at a distance about 40 kilometers away from the mine. Nevertheless, the seismic stability of the final pit wall has not been comprehensively reviewed. In this research, the southwestern wall of the final p...

The mammalian pit-1 gene encodes a 33 kd transcription factor (1,2) expressed in a subset of endocrine cells of the anterior pituitary (3). Pit-1 is structurally related to the POU family of transcriptional regulators (4), containing a characteristic POU domain divided into two regions, the POU-specific and homeo subdomains. Located in the C-terminal half of the protein, the POU domain is criti...