نتایج جستجو برای: ژن tsga10
تعداد نتایج: 15794 فیلتر نتایج به سال:
Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autosomal recessive disorder. Autoimmune gonadal failure is often one of its features. The aim of this study was to identify targets of immune reactions associated with male autoimmune hypogonadism in APS1. Human testis cDNA expression library immunoscreening with APS1 patients' sera identified the protein testis-specific prote...
زمینه و هدف: اختلال در بیان هر یک از ژن های مؤثر در مسیر اسپرماتوژنز به عنوان یکی از عوامل احتمالی ایجاد آزواسپرمی غیرانسدادی و ناباروری مردان مطرح می باشد. در این میان نحوه بیان ژن های مؤثر در توانایی حرکت اسپرم نیز می تواند تأثیر قابل توجهی بر باروری مردان داشته باشد. مطالعات اخیر نشان می دهد ژن tsga10 در انجام روند طبیعی اسپرماتوژنز مؤثر می باشد، به طوری که پروتئین حاصل از این ژن در موش منجر...
in this study tsga10 has been demonstrated as a testis-specific human gene that encodes a protein localized in sperm-tail and conserved in ciliary structure. further investigations showed tsga10 signalling and expression during embryogenesis, brain development and some malignancies including brain tumors. given the role of this protein in neuronal development and in certain tumors, it could pot...
Cancer/Testis antigens (CTAs) as a group of tumor antigens are the novel subjects for developing cancer vaccine and immunotherapy approaches. They aberrantly express in tumors with highest normal expression in testis, and limited or no expression in normal tissues. There are important similarities between the processes of germ-cell and cancer cell development Spermatogenesis begins at puberty w...
background breast cancer is the most common malignancy in women around the world so finding new biomarkers for early detection and also study on molecular aspects of breast cancer is valuable. cancer testis genes are a group of genes expressed solely in testis and in a range of human malignancies. objectives in this study we determined the expression of cancer testis genes tsga10, tex101 and od...
Background: About 15% of couples have fertility problems and male factor in fertility accounts for half of the cases. In vitro generation of germ cells introduces a novel approach to male infertility and provides an effective system in gene tracking studies, however many aspects of this process have remained unclear. We aimed to promote mouse embryonic stem cells (mESCs) differentiation into ge...
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