Objective To evaluate if COmbinatie therapie Bij Reumatoïde Artritis (COBRA)-light therapy is cost-effective in treating patients with early rheumatoid arthritis (RA) compared with COBRA therapy. Methods This economic evaluation was performed next to the open-label, randomised non-inferiority COBRA-light trial in 164 patients with early RA. Non-responders to COBRA or COBRA-light received etan...

Cobra-F64a and Cobra-F64b, designed for firmware-oriented applications, are 64-bit Data-dependent Permutation based block ciphers with 128 key bits, which consist of 16 and 20 rounds, respectively. In this paper, we investigate their security against related-key attacks. Our investigation shows that the full 16-round Cobra-F64a can be broken by our related-key rectangle attack and that the full...

BACKGROUND The Combinatietherapie Bij Reumatoide Artritis (COBRA) trial has proved that combination therapy with prednisolone, methotrexate and sulphasalazine is superior to sulphasalazine monotherapy in suppressing disease activity and radiological progression of early rheumatoid arthritis (RA). In addition, 5 years of follow-up proved that COBRA therapy results in sustained reduction of the r...

BACKGROUND This study aimed to evaluate the applicability of Cobra perilaryngeal airway (Cobra PLA™) for obese patients under general anesthesia and also to compare the results with those of classic laryngeal mask airway (LMA™). MATERIALS AND METHODS Seventy-three overweight and obese patients were included in this study. The patients were randomly assigned to LMA™ or Cobra PLA™ groups. Time ...

This work addresses applications of the classical harmony search (HS), improved harmony search (IHS) and the harmony search with differential mutation based pith adjustment (HSDM) to PWR core reloading pattern optimization problems. Proper loading pattern of fuel assemblies (FAs) depends on both neutronic and thermal–hydraulic aspects; obtaining optimal arrangement of fuel assemblies, FA, in a ...

El cálculo del tamaño muestral estima el número de participantes que serán necesarios para demostrar efecto considerado como clínicamente importante, si este existe. En caso los estudios supervivencia cobra más importancia sucesos es preciso observar, a partir cual se calculará necesarios.

This document describes COBRA-ONT an ontology for supporting pervasive context-aware systems. COBRA-ONT, expressed in the Web Ontology Language OWL, is a collection of ontologies for describing places, agents, events and their associated properties in an intelligent meeting room domain. This ontology is developed as a part of the Context Broker Architecture (CoBrA), a broker-centric agent archi...

2 The 'full title of COBRA' COBRA network developed a joint survey instrument to study the autonomy and control of semi-autonomous agencies and is coordinated by the Public Management Institute – University of Leuven. COBRA members of the following countries were involved in the collection of survey data which was used for this article: Belgium (Flanders) Gothenburg).. We owe many thanks to the...

The low potency of cobra antivenom has been an area of concern in immunotherapy for cobra envenomation. This study sought to investigate factors limiting the neutralizing potency of cobra antivenom, using a murine model. We examined the immunological reactivity and neutralizing potency of a Thai polyvalent antivenom against the principal toxins of Naja sumatrana (Equatorial spitting cobra) veno...

Cobra snakebites are one of the most frequent occurrences among the poisonous snakebites. The correlation between the serum concentrations of cobra venom in the victims with the severity of systemic and local symptoms after envenoming is still awaited for investigation. In this paper, we have developed an enzyme-linked immunosorbent assay (ELISA) to detect Taiwan cobra venom existed in the seru...