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We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, -B, and -C were typed to 4-digit resolution using sequence-based typing method. HLA class I haplotype frequencies were estimated using PyPop 32-0.6.0. The influence of haplotype...
Dengue is one of the most globally serious vector-borne infectious diseases in tropical and subtropical areas for which there are currently no effective vaccines. The most highly conserved flavivirus protein, NS5, is an indispensable target of CD8+ T-cells, making it an ideal vaccine design target. Using the Immune Epitope Database (IEDB), CD8+ T-cell epitopes of the dengue virus (DENV) NS5 pro...
BACKGROUND Data on allele frequencies (AFs) and haplotype frequencies (HFs) of HLA-C and -DQB1 are limited in Koreans. We investigated AFs and HFs of HLA-A, -B, -C, -DRB1, and -DQB1 in Koreans by high-resolution sequence-based typing (SBT). METHODS Hematopoietic stem cells were obtained from 613 healthy, unrelated donors to analyze HLA-A, -B, -C, -DRB1, and -DQB1 genotypes by using AlleleSEQR...
Human leukocyte antigen (HLA) antibodies represent a significant risk factor for transplant failure. It is very important to characterize anti-HLA antibodies as epitopes rather than antigens so that this knowledge can be applied clinically. The aim of the study was to investigate the extra reactivity patterns in sensitized multipare. Here, we have used the HLAMatchmaker program, a theoretical a...
INTRODUCTION Genetic predisposition to multiple sclerosis (MS) in Sardinia (Italy) has been associated with five DRB1*-DQB1* haplotypes of the human leukocyte antigen (HLA). Given the complexity of these associations, an in-depth re-analysis was performed with the specific aims of confirming the haplotype associations; establishing the independence of the associated haplotypes; and assessing pa...
Energy required for vehicles Low case High case A1(S1) 2007 onroad vehicle miles traveled in the U.S. (mi/yr) 3.237E+12 3.237E+12 A2 (S2) Total onroad vehicle fleet mileage (mpg) 1.711E+01 1.711E+01 A3=A1/A2 Gallons of fuel (gas+diesel) used (gal/yr) 1.892E+11 1.892E+11 A4 Lower heating value gasoline (MJ/kg) 4.400E+01 4.400E+01 A5 Gasoline density (kg/m3) 7.500E+02 7.500E+02 A6 Gallons per cub...
P mparison with Brazilian populations. The genotypes RHCE*Ee, K ore prevalent in the population from the state of Santa Catarina i *Cc, RHCE*cc, RHCE*ee, FY*01/FY*02, FY*01/FY*02.N01, FY*02/FY*02, F ypes were more common in the population from the state of S erved in the comparison with Brazilian populations. The genot JK*02/02 were more prevalent in the population from the state of S ddition, ...
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