• The survival outcomes for first-line ipilimumab were modelled, in the SMC base case model, using data from the Phase III RCT CA184-024, due to local requirements of the SMC. However, as the CA184-024 trial contained an unlicensed 10mg/kg dose of ipilimumab and the combination with DTIC (licensed dose is 3mg/kg), multiple sources were used to produce a range of reliable estimates of the increm...

In this paper, the metabolic activity in single and dual species biofilms of Staphylococcus epidermidis and Staphylococcus aureus isolates was investigated. Our results demonstrated that there was less metabolic activity in dual species biofilms compared to S. aureus biofilms. However, this was not observed if S. aureus and S. epidermidis were obtained from the same sample. The largest effect o...

Pramod N. Achar Spring 2000 In this problem set you will prove an analogue of the Fundamental Theorem of Calculus, Stokes’ Theorem, etc. To set up the context of the problem, let us define an operator div◦ on vector fields on R by div◦(P (x, y)i + Q(x, y)j) = ∂Q ∂x − ∂P ∂y . Let C denote a curve in R with endpoints a and b. Let S denote a surface whose boundary is the closed curve BdS. Let V de...

Background: Pain is one of the most bothersome symptoms reported in Parkinson’s disease (PD), yet its underlying pathophysiological mechanisms are not well understood. Its prevalence and effects on quality life patients with monogenic forms PD have been systematically explored. Methods: Comprehensive literature review exploring association between ( SNCA , PRKN PINK1 DJ1 LRRK2 ) pain. We includ...

Background Cancer cachexia impacts the majority of advanced cancer patients but no approved anticachexia therapeutic exits. Recent late stage clinical failures of anabolic anti-cachexia therapy revealed heterogeneous responses to anabolic therapies and a limited ability to translate improved body composition into functional benefit. It is currently unclear what governs anabolic responsiveness i...

Some applications of Bayesian decision theory to intelligent tutoring systems are considered. How the problem of adapting the appropriate amount of instruction to the changing nature of a student's capabilities during the learning process can be situated in the general framework of Bayesian decision theory is discussed in the context of the Minnesota Adaptive Instructional System (MAIS) . Two b...

Inverses and determinants of matrices are closely related and come up in many different contexts. In these notes we will develop some basics of the theory of these ideas. Our initial motivation is the solution of systems of linear equations, such as 2x − 5y + 4z = −3 x − 2y + z = 5 x − 4y + 6z = 10. To solve the system, we want to manipulate these equations to get new equations which only conta...

This article shows the process of transition from unitary state to decentralisation, which is transfer administrative competences central communities (municipalities). law derived Constitution 18 January 1996, was re-enacted by Law No. 2019/024 24 December 2019 on General Code Decentralised Territorial Authorities, with creation regions and elected regional councillors traditional chiefs appoin...