RESISTANCE TO ENDOCRINE THERAPY IN BREAST CANCERKerrie Bouker, Yuelin Zhu, Rebecca Riggins, Alan Zwart, Ruchi Nehra, BiancaGomez, and Robert ClarkeLombardi Comprehensive Cancer Center, Department of Oncology, GeorgetownUniversity, Washington D.C. 2007clarker@ georgetown.eduThe precise mechanisms of resistance to endocrine therapies are unclear. Antiestrogen-stimulate...

Standard-dose heparin protocol (SDP) is the standard anticoagulant of unfractionated (UFH) for maintenance hemodialysis. To alleviate side effect heparin, low-dose (LDP) has been proposed, however, studies were scarce and inconclusive.

While laboratory and clinical benefits of hydroxyurea for patients with sickle cell disease (SCD) are well-established, few data describe the extent and implications of non-adherence. We sought to assess adherence to hydroxyurea among patients with SCD and investigate associations between adherence and clinical and economic outcomes. Insurance claims of North Carolina Medicaid enrollees (6/2000...

∗We are extremely thankful for many constructive suggestions from Gurdip Bakshi, N. Chidambaran, Darrell Duffie, Rong Fan, Gifford Fong, John Knight, N. R. Prabhala, Jun Pan, Dmitry Pugachevsky, Shuyan Qi, Ken Singleton, Rangarajan Sundaram, Suresh Sundaresan and Haluk Unal. We received useful feedback from participants at various seminars: at the AIMR talks in Tokyo, Singapore and Sydney, the ...

BACKGROUND AND PURPOSE A precise analysis of the immediate postoperative anatomic results in a large series of unruptured intracranial aneurysms treated by endovascular approach has not previously been presented. This study aimed to assess the efficacy of endovascular treatment of unruptured intracranial aneurysms in light of immediate postoperative anatomic results in a prospective, multicente...

Proponents of usage-based models [Bybee, J.L., 1995. Regular morphology and the lexicon. Language and Cognitive Processes 10, 425–455; Langacker, R.W., 2000. A dynamic usage-based model. In: Barlow, M., Kemmer, S. (Eds.), Usage-Based Models of Language. CSLI Publications, Stanford, CA, pp. 1–63; Tomasello, M., 2003. Constructing a Language: A Usage-Based Theory of Child Language Acquisition. Ha...

BACKGROUND Central nervous system (CNS) events are frequently reported among patients with advanced prostate cancer as a consequence of the treatments used in this patient population. OBJECTIVE To assess the incidence of CNS events in patients with advanced prostate cancer who initiated treatment with abiraterone acetate, bicalutamide, enzalutamide, or chemotherapy. METHODS The Truven Healt...