The roles of cellular proteases in Moloney murine leukemia virus (MLV) infection were investigated using MLV particles pseudotyped with vesicular stomatitis virus (VSV) G glycoprotein as a control for effects on core MLV particles versus effects specific to Moloney MLV envelope protein (Env). The broad-spectrum inhibitors cathepsin inhibitor III and E-64d gave comparable dose-dependent inhibiti...

Recent studies have linked necrotic cell death and proteolysis of inflammatory proteins to the adaptive immune response mediated by the lysosome-destabilizing adjuvants, alum and Leu-Leu-OMe (LLOMe). However, the mechanism by which lysosome-destabilizing agents trigger necrosis and proteolysis of inflammatory proteins is poorly understood. The proteasome is a cellular complex that has been show...

The invasion and replication of Eimeria tenella in the chicken intestine is responsible for avian coccidiosis, a disease that has major economic impacts on poultry industries worldwide. E. tenella is transmitted to naïve animals via shed unsporulated oocysts that need contact with air and humidity to form the infectious sporulated oocysts, which contain the first invasive form of the parasite, ...

1 Laboratoire Pierre Aigrain, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris Cedex 5, France 2 CNRS UMR8551, Université Pierre et Marie Curie, 24 rue Lhomond, 75005 Paris, France 3 Laboratoire de Physico-Chimie des Matériaux Luminescents, Université Lyon 1, Université de Lyon, Campus de la Doua, 69622 Villeurbanne, France 4 Université Montpellier 2, CC 074, 34095 Montpellier Cedex 5, France

Molecular nanoribbons are a class of atomically-precise nanomaterials for broad range applications. An iterative approach that allows doubling the length longest pyrene-pyrazinoquinoxaline molecular is described. The largest nanoribbon obtained through this approach—with 60 linearly-fused ring backbone (14.9 nm) and 324-atoms core (C276N48)—shows an extremely high molar absorptivity (values up ...

No presente artigo foram analisadas as mortes decorrentes de infecção do trato respiratório ou por pneumonia nos anos 2016, 2017, 2018 e 2019 nas regiões Brasil no páis. Assim, esta pesquisa tem objetivo compilar, analisar estimar a taxa morte inferior cada 100 mil habitantes, em âmbito nacional regional, disponibilizados banco dados Sistema Informações sobre Mortalidade (SIM) domínio público s...