Sigma-1 receptor antagonists promote antinociception in several models of pain, but the effects of sigma-1 agonists on nociception (particularly when the nociceptive system is primed) are not so well characterized; therefore we evaluated the effects of sigma-1 agonists on pain under different experimental conditions. The systemic administration of the selective sigma-1 agonists (+)-pentazocine ...

A previous study showed that cocaine self-administration induced dopamine-independent reinforcing effects of s agonists mediated by their selective actions at s1 receptors (s1Rs), which are intracellularly mobile chaperone proteins implicated in abuserelated effects of stimulants. The present study assessed whether the induction was specific to self-administration of cocaine. Rats were trained ...

Substrate based scar modification requires accurate detection and characterization of myocardial in sinus rhythm or using different wavefronts activation. Mapping during ventricular tachycardia can be performed only about 30% to 40% cases. We describe a challenging case VT with discrepancy the delineation between voltage mapping cardiac MRI role Decremental Evoked Potential as guide more focuss...

Alfred Christiaan SCHOUTEN werktuigkundig ingenieur geboren te Dordrecht, Nederland. Het onderzoek beschreven in dit proefschrift is mede mogelijk gemaakt door financiële on-dersteuning van de Nederlandse organisatie voor wetenschappelijk onderzoek, medische wetenschappen (NWO-MW, project nummer: 902-36-084). De pols manipulator beschreven in dit proefschrift is mede mogelijk gemaakt door een g...

Positive solutions and eigenvalue intervals for nonlinear systems JIFENG CHU1,2, DONAL O’REGAN3 and MEIRONG ZHANG1 1Department of Mathematical Sciences, Tsinghua University, Beijing 100 084, China 2Department of Applied Mathematics, Hohai University, Nanjing 210 098, China 3Department of Mathematics, National University of Ireland, Galway, Ireland E-mail: [email protected]; [email protected]...

ISMIHAN BAIRAMOV, SAMUEL KOTZ and TOMASZ J. KOZUBOWSKI* Izmir University of Economics, Department of Mathematics, Sakarya Caddesi 156, 35330 Izmir, Turkey; Dept. of Engineering Management and Systems Engineering, School of Engineering and Applied Science, George Washington University, 1776=G Street, N.W., Washington, DC 20052, USA; University of Nevada, Dept. of Mathematics=084, Reno, NV 89557-...

Alzheimer's disease (AD), the most prevalent dementia in the elderly, is characterized by progressive synaptic and neuronal loss. Mitochondrial dysfunctions have been consistently reported as an early event in AD and appear before Aβ deposition and memory decline. In order to define a new neuroprotectant strategy in AD targeting mitochondrial alterations, we develop tetrahydro-N,N-dimethyl-2,2-...

A previous study showed that cocaine self-administration induced dopamine-independent reinforcing effects of σ agonists mediated by their selective actions at σ1 receptors (σ1Rs), which are intracellularly mobile chaperone proteins implicated in abuse-related effects of stimulants. The present study assessed whether the induction was specific to self-administration of cocaine. Rats were trained...