Dual inhibitor studies were performed to examine the interaction of aphidicolin, phosphonoformate, 9-(2-hydroxyethoxymethyl)guanine triphosphate, and 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate with herpes simplex virus DNA polymerase. Kinetic data indicated that inhibition by one agent prevents simultaneous inhibition by a second agent, producing a mutually exclusive inhibition patte...

Compound BW759 (9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine) was shown to be about 230 times more active than acyclovir (9-[2-hydroxyethoxymethyl]guanine) (ACV) against Equid herpesvirus type 1 infection in Syrian hamsters and was more effective against Aujeszky's disease in mice. The therapeutic superiority of BW759 over ACV was greater than expected from quantitative inhibitory results...

more potent drugs have become available. Arabinoside adenine and trifluorothymidine (TFT) are both effective and relatively nontoxic alternatives widely used in the management of herpetic disease.' Acyclovir (ACV) (9-(2-hydroxyethoxymethyl) guanine)2 and (E)-5(2-bromovinyl)-2' deoxyuridine),3 recently developed antiviral compounds with potent inhibitory activity against herpes simplex DNA polym...

‎in our paper [a‎. ‎b‎. ‎m‎. ‎basheer and j‎. ‎moori‎, ‎on a group of the form $2^{10}{:}(u_{5}(2){:}2)$] we calculated the inertia factors‎, ‎fischer matrices and the ordinary character table of the split‎ ‎extension $ 2^{10}{:}(u_{5}(2){:}2)$ by means of clifford-fischer‎ ‎theory‎. ‎the second inertia factor group of $2^{10}{:}(u_{5}(2){:}2)$‎ ‎is a group of the form $2_{-}^{1+6}{:}((3^{1+2}{...