ankylosing spondylitis (as) is an inflammatory arthritis, which affects mainly spine and sacroiliac joints. according to recent studies, erap1 is the second most common candidate gene for  as susceptibility after hla-b27. the  aim of this study was to  determine the association of erap1 gene polymorphisms with as in iranian population. the study group comprised 387 iranian as patients and 316 h...

background: for the first time we tested an association between the human multidrug resistance gene 1 (mdr1) polymorphisms (snps) and idiopathic pulmonary fibrosis (ipf). several mdr1 polymorphisms are associated with pathologies in which they modify the drug susceptibility and pharmacokinetics. materials and methods: we genotyped three mdr1 polymorphisms of 48 ipf patients and 100 control subj...

intercellular adhesion molecule-1 (icam-1) lys469glu (k469e) polymorphism and gly 241arg (g241r) polymorphism might play important roles in cancer development and progression. however, the results of previous studies are inconsistent. the aim of this study was to evaluate the association between icam-1 k469e and g241r polymorphisms and the risk of cancer by meta-analysis.a comprehensive literat...

objectives in this study, the association of tgf-β1 +915g/c and -509c/t gene polymorphisms with chronic hepatitis b was evaluated in iranian patients. materials and methods a population-based case–control study was conducted in taleghani hospital, tehran. a number of 220 patients with chronic hepatitis b and the same number of healthy control subjects were designated the case and the control gr...

background uterine leiomyoma (uls) is the most common gynecological tumor and a significant health concern for many women .the interleukin-1 receptor antagonist (il-1ra) is a naturally occurring cytokine inhibiting interleukin- 1 (il-1) activity by binding to the il-1 receptors without signal transduction. objectives the aim of this study was to investigate the association between interleukin-1...

compelling evidence suggests that the oxidative stress plays a key role in the pathophysiology of cardiovascular disease (cvd). superoxide dismutase (sod) enzymes play a major role in detoxification of reactive oxygen species and protection against oxidative stress. we examined the possible association between a 50-bp insertion/deletion in the sod1 promoter 1684-bp upstream of the sod1 atg with...

background: xmn-1 polymorphism of y g globin gene ( hbg2 ) is a prominent quantitative trait loci (qtl) in β-thalassemia intermediate (β-ti). in current study, we evaluated frequency of xmn-1 polymorphism and its association with β-globin gene ( hbb ) alleles and hb f level in β-ti patients in sistan and balouchestan province, south-east of iran. methods: 45 β-ti patients were enrolled. hbb gen...