Milbemycins are a family of sixteen-membered macrolides produced by Streptomyces hygroscopicus subsp. aureolacrimosus. They exhibit broadspectrum insecticidal and acaricidal activity. * ~ 3) In the course of our studies on the microbial conversion of milbemycins, we obtained 13/?hydroxymilbemycins A3 (2b), A4 (lb), and D (3b) from milbemycins A3 (2a), A4 (la), and D (3a), respectively, and 1 3j...

1. On Day 10 of the oestrous cycle in pigs, after laparotomy noradrenaline (NA), methoxamine (alpha 1-adrenomimetic, M), Prazosin (alpha 1-adrenolytic, Pr) in total doses of 4 mumol, and saline were infused (10 min) into the superficial layer of mesovarium on both sides of the ovarian pedicle vasculature, close to the ovary. 2. Blood flow in the ovarian artery, heart rate and progesterone (P4) ...

Infected cell protein no. 4 (ICP4), the major regulatory protein encoded by the a4 gene of herpes simplex virus 1, binds to a site (a4-2) at the transcription initiation site of the a4 gene. An earlier report described the construction of recombinant viruses that contained chimeric genes (a4-tk) that consisted of the 5* untranscribed and transcribed noncoding domains of the a4 gene fused to the...

CONTEXT Up-regulation of aromatase expression in endometrial cells disseminated into the peritoneal cavity may enhance their survival via local estrogen synthesis, which may lead to endometriosis. The factors that mediate induction of aromatase in the endometrium are not well defined, but increased expression of steroidogenic factor (SF)-1 may play a role. OBJECTIVE The objective of the study...

Hematopoiesis is regulated by two sets of signals, those generated by cytokines and those generated when precursor cells interact with bone marrow (BM) stroma. The intimate contact between precursors and stroma appears to be mediated by multiple, different receptor-ligand binding events. To identify receptor-ligand pairs mediating the adhesion of hematopoietic precursor cells to stroma, an in v...

In the context of A4 symmetry, neutrino tribimaximal mixing is achieved through the breaking of A4 to Z3 (Z2) in the charged-lepton (neutrino) sector respectively. The implied vacuum misalignment of the (1,1,1) and (1,0,0) directions in A4 space is a difficult technical problem, and cannot be treated without many auxiliary fields and symmetries (and perhaps extra dimensions). It is pointed out ...

The salient pathological feature of Alzheimer disease (AD) is the presence of a high density of amyloid plaques in the brain tissue of victims. The plaques are predominantly composed of human beta-amyloid peptide (beta A4), a 40-mer whose neurotoxicity is related to its aggregation. Radioiodinated human beta A4 is rapidly deposited in vitro from a dilute (less than 10 pM) solution onto neuritic...

The appropriate development of an inflammatory response is central for the ability of a host to deal with any infectious insult. However, excessive, misplaced, or uncontrolled inflammation may lead to acute or chronic diseases. The microbiota plays an important role in the control of inflammatory responsiveness. In this study, we investigated the role of lipoxin A4 and annexin-1 for the IL-10-d...

I propose a model of radiative charged-lepton and neutrino masses with A4 symmetry. The soft breaking of A4 to Z3 lepton triality is accomplished by dimension-three terms. The breaking of Z3 by dimension-two terms allows cobimaximal neutrino mixing (θ13 6= 0, θ23 = π/4, δCP = ±π/2) to be realized with only very small finite calculable deviations from the residual Z3 lepton triality. This constr...

Gankyrin, a recently discovered oncoprotein, is a promising target for drug therapy because it is overexpressed in most hepatocellular carcinomas. Since gankyrin interacts with MAGE-A4, we made several MAGE-A4 mutants and assessed their effects on cell growth. We found that the C-terminal 107 amino acids of MAGE-A4 (MAGE-A4DeltaN1) induced p53-dependent and p53-independent apoptosis. MAGE-A4Del...