Background: Tocilizumab (TCZ) is a monoclonal antibody that binds to the interleukin 6 receptor (IL-6R), inhibiting IL-6R signal transduction downstream inflammatory mediators. TCZ has shown be effective as monotherapy in early rheumatoid arthritis (RA) patients (1). However, approximately one third of inadequately respond therapy and biological mechanisms underlying lack efficacy for remain el...

Full: HTML / PDF (387K) Select Citation Influence of Storage Conditions on the Structure, Thermal Behavior, and Formation of EnzymeResistant Starch in Extruded Starches Hélène Chanvrier, Surjani Uthayakumaran, Ingrid A. M. Appelqvist, Michael J. Gidley, Elliot P. Gilbert, and Amparo López-Rubio pp 9883 9890; (Article) DOI: 10.1021/jf071974e Abstract Full: HTML / PDF (188K) Select Citation Use o...