نتایج جستجو برای: 105
تعداد نتایج: 30068 فیلتر نتایج به سال:
there has been a highly significant increase in the number of patients with malignant mediastinal tumors in the last four decades. since these lesions are infrequently encountered and there are very few reports in iran concerning this issue, we performed this study to review our institutional experience of medias-tinal masses and to compare differences in the clinical spectrum between our study...
A high-throughput screening campaign was conducted to interrogate a 380,0001 small-molecule library for novel D2 dopamine receptor modulators using a calcium mobilization assay. Active agonist compounds from the primary screen were examined for orthogonal D2 dopamine receptor signaling activities including cAMPmodulation and b-arrestin recruitment. Although themajority of the subsequently confi...
Several studies have shown that renal failure decreases CYP3A activity and that uremic toxins may play a role via transcriptional or translational modifications of cytochrome P450 (P450) enzymes and direct inhibition of P450-mediated metabolism. In this study, we evaluated the relationship between CYP3A activity (using plasma concentration of 4b-hydroxycholesterol as a biomarker) and clinical c...
The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions with p-aminobenzoic acid and trimethoprim suggested that a sulfonamidelike mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed ...
We evaluated the efficacy, potency, and selectivity of the three most commonly used adenylate cyclase (AC) inhibitors in a battery of cell lines constructed to study signaling via three discrete cAMP sensors identified in neuroendocrine cells. SQ22,536 [9-(tetrahydrofuryl)-adenine] and 29,59-dideoxyadenosine (ddAd) are effective and potent AC inhibitors in HEK293 cells expressing a cAMP respons...
Carriers of bovine anaplasmosis in Northern Kerala, South India were detected using conventional microscopical and molecular techniques. PCR-RFLP and nested PCR techniques were used for detection of Anaplasma marginale and Anaplasma bovis respectively and the PCR products were confirmed by sequencing. Out of 150 samples tested, 25 were detected positive for A. marginale and five for A. bovis ba...
A new one-dimensional clarifier model was developed, including components of existing models, and extended with a height-dependent cross-sectional area and two flowrate-dependent dispersion coefficients. This model is evaluated using data from a detailed one-month measuring campaign on a full-scale wastewater treatment plant. The data included hourly sludge concentration profiles, sludge bed he...
We analyzed RXTE data of GRS 1915+105 of X-ray low states between 1996 and 1998. The X-ray spectrum is dominated by the power law component. We found (i) that the power law is pivoting at 10-30 keV, (ii) that the power law slope correlates with radio flux, (iii) three different groups of 3-10 keV residuals, (iv) that one of these residual groups correlates with the power law slope. The prototyp...
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