The effect of neem, Azadirachta indica A. Juss, on ultrastructural alteration of larvae and puparia of the blow fly, Chrysomya megacephala (Fabricius) (Diptera: Calliphoridae) and house fly, Musca domestica (Linnaeus) (Diptera: Muscidae), was investigated in the laboratory by using neem extract containing 0.24% azadirachtin A. Larvae of both species exposed to single dipping with the neem produ...

Günümüzde geliþen teknolojinin bize sunduðu pozitron emisyon tomografi (PET), magnetoensefalografi, tek foton emisyon komputerize tomografi (SPECT), bilgisayarlý beyin tomografisi, manyetik rezonans gibi görüntüleme yöntemleri ile birlikte elektroensefalografi (EEG) (uyarýlmýþ potansiyeller ve olaya iliþkin potansiyeller de dahil olmak üzere) sadece araþtýrma amaçlý deðil doðrudan klinik uygula...

Core planar cell polarity (PCP) proteins are well known to regulate polarity in Drosophila and vertebrate epithelia; however, their functions in vertebrate morphogenesis remain poorly understood. In this study, we describe a role for PCP signaling in the process of apical constriction during Xenopus gastrulation. The core PCP protein Vangl2 is detected at the apical surfaces of cells at the bla...

NATURE | VOL 411 | 3 MAY 2001 | www.nature.com 107 21. Blasina, A. et al. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Curr. Biol. 9, 1±10 (1999). 22. Liu, F., Rothblum-Oviatt, C., Ryan, C. E. & Piwnica-Worms, H. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular traf®cking of Cdc2-cyclin B1 complexes. ...

Understanding drug glucuronidation in the dog, a preclinical animal, is important but currently poorly characterized at the level of individual enzymes. We have constructed cDNAs for the 10 dog UDP-glucuronosyltransferases of subfamily 1A (dUGT1As), expressed them in insect cells, and assayed their activity as well as the activity of the nine human UGT1As, toward 14 compounds. The goal was to f...

Purpose: The aim of this study was to clinically evaluate immediate functionally loaded (IFL) and immediate nonfunctionally loaded (INFL) implants for various indications compared to a control group with a conventional healing period. Materials and Methods: Two hundred fifty-three patients took part in the study. A total of 702 XiVE implants (Dentsply/Friadent, Mannheim, Germany) were placed: 2...

In this assessment we summarise advances in our knowledge of how UV-B radiation (280–315 nm), together with other climate change factors, influence terrestrial organisms and ecosystems. We identify key uncertainties and knowledge gaps that limit our ability to fully evaluate the interactive effects of ozone depletion and climate change on these systems. We also evaluate the biological consequen...

It is known that penicillin resistance of bacteria is mainly caused by the inactivation of penicillin by penicillinase derived from such strains. We have developed a screening procedure for penicillinase inhibitors. Several microorganisms were found to produce such inhibitors, and from the culture filtrate of Streptomyces gedanensis ATCC 4880 a penicillinase inhibitor, named KA-107, was isolate...