1,3-dibromo-5,5-dimethylhydantoin (dbh), as a cheap and commercially available reagent, is efficiently able to catalyze the synthesis of polyhydroquinoline derivatives and 12-aryl-8,9,10,12-tetrahydro[a] xanthene-11-ones via one-pot multi-component reactions. this novel synthetic method has the advantages of low cost and availability of the catalyst, short reaction times, high to excellent yiel...

Proof: Just pick g at random. For every particular 2 √ n-time algorithm A, the expected number of inputs on which A(x) = g(x) is one, and the probability that A computes g successfully on an at least 2−n/10 fraction of the total 2n inputs can be shown to be less than 2−2 −n/2 . But a 2 √ n algorithm can be described by about 2 √ n 2n/2 bits and so the total number of such algorithms is much sma...

Five new 2,9,9-trimethyl-6,7,8,9-tetrahydro-benzocyclohepten-5-ylidene-amine derivatives (16a-16e) were synthesized from α-dehydro-ar-himachalene (11) that was originally prepared from an isomeric mixture of α, β and γ himachalenes (10), the abundant sesquiterpenes of Cedrus deodara essential oil. In addition, different aryl himachalenes derivatives (9, 12, 14 and 15) were also formed from 11. ...

8β-Hydroxy-9(11),13-abietadien-12-one (1), an abietane diterpenoid and aryl hydrocarbon receptor (AhR) ligand, was synthesized in six steps from commercially available (+)-dehydroabietylamine (2). We used the hypervalent iodine catalyst phenyliodine dicarboxylate, a safer alternative to toxic organoselenide reagents, for oxidative dearomatization of ferruginol (7) compound 1. Compounds 1 2, as ...

An environmentally friendly, facile and solvent-free synthetic route for aluminum sulfate octadecahydrate (Al2(SO4)3.18H2O) catalyzed one-pot multi-component synthesis of 12-aryltetrahydrobenzo[α]xanthene-11-ones, 1,8-dioxo-octahydroxanthenes and 14-aryl-14Hdibenzo[α,j]xanthenes has been developed. The readily, easy to handle, non-toxic, environmental friendly and low-cost catalyst, easily sepa...

To find new and better antivascular agents for cancer therapy, a series of combretastatin A4 (CA4) analogs were prepared from 1,3-diaryl-2-nitroprop-1-enes (6-12) obtained in a two-step synthesis from appropriate arylaldehydes and 2-aryl-1-nitroethanes (4 or 5). Treatment of these 1,3-diaryl-2-nitroprop-1-enes 6-12 by sodium azide in DMSO yielded the targeted compounds. The synthesized 1,2,3-tr...

in the present work, novel 7-aryl-10, 11-dihydro-7h-chromeno [4, 3-b]quinoline-6, 8(9h, 12h)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7h-chromeno[4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/nano2 with yields of 64-74%. cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (k562, ls180...