The repair of injured tendons remains a great challenge, largely owing to a lack of in-depth characterization of tendon cells and their precursors. We show that human and mouse tendons harbor a unique cell population, termed tendon stem/progenitor cells (TSPCs), that has universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity. The isolated TSPCs could r...

background:  we aimed to report outcomes of total hip arthroplasty (tha) in very young patients under the year of 30.   methods:  thirty patients (45 hips) with various indications for tha were retrospectively reviewed radiologically and clinically and analyzed regarding survival, reasons of failure, factors associated with outcomes and postoperative complications.   results:  within a mean fol...

Introduction: Total hip arthroplasty (THA) after proximal femoral fixation is a challenging procedure due to possible hardware-related complications. Case presentation: A 78-year-old female with hip osteoarthritis had a proximal femoral osteotomy fixed using a blade plate in the same femur 41 years ago. A two-step approach was planned. After a challenging...

Novel genetically engineered mouse models using the Cre-loxP or the Flp-FRT systems have generated useful reagents to manipulate the mouse genome in a temporally-regulated and tissue-specific manner. By incorporating a constitutive Cre driver line into a mouse model in which FRT-regulated genes in other cell types are regulated by Flp-FRT recombinase, gene expression can be manipulated simultan...

a breeding hexaploid salt tolerant wheat line (ms-81-14) was produced from crossing of an iranian salt tolerant wheat line (1-66-22) with inia cultivar (from cimmyt) at karaj research station in 1991-92 cropping season. the f1 plants were grown at karaj in 1992-93 cropping season, furthermore f2-f6 populations were evaluated under salinity stress conditions (ecsoil&water; = 8-12 ds/m) in isfaha...

Alexandra Moores, Saranna Chipper-Keating, Lei Sun, Gareth McVicker, Lynn Wales, Krishna 6 Gashi and Ian C. Blomfield* 7 8 School of Biosciences, University of Kent, Canterbury, Kent 9 CT2 7NJ, United Kingdom 10 11 12 * Corresponding author. E-mail: [email protected]; Phone (0)1227 823697; Fax (0)1227 13 763912 14 Running Title: RfaH suppresses MicA inhibition 15

word count: 209 Full text word count: 15,305 Figures: 3 Address correspondence to: Elliot Berkman [email protected] 1227 University of Oregon Eugene, OR USA 97403-1227 Phone: 541-346-4909 Fax: 541-346-4911 IN PRESS AT PSYCHOLOGICAL INQUIRY IDENTITY-VALUE MODEL 2

Nitidine chloride (NC), a quaternary ammonium alkaloid, has numerous pharmacological effects, such as anticancer activity. However, it was found that NC also has hepatocellular toxicity. Because organic cation transporters 1 and 3 (OCT1 and OCT3) might mediate the influx of NC into hepatocytes, multidrug and toxin extrusion 1 (MATE1) probably mediates the efflux of NC from hepatocytes, while cy...

Hox genes encode homeodomain transcription factors that control morphogenesis and have established functions in development and evolution. Hox proteins have remained enigmatic with regard to the molecular mechanisms that endow them with specific and diverse functions, and to the cellular functions that they control. Here, we review recent examples of Hox-controlled cellular functions that highl...

People and animals often demonstrate strong attraction or aversion to options with uncertain or risky rewards, yet the neural substrate of subjective risk preferences has rarely been investigated. Here we show that monkeys systematically preferred the risky target in a visual gambling task in which they chose between two targets offering the same mean reward but differing in reward uncertainty....