The murine monoclonal antibody OC125 reacts with an antigenic determinant (CA 125) found on a high-molecular-weight glycoprotein complex present in the serum of greater than 80% of women with epithelial ovarian cancer. The antigen expressing CA 125 (CA 125 antigen) isolated from the sera of ovarian carcinoma patients was shown by gel electrophoresis, molecular size exclusion chromatography, and...

Human antisera against Australia (Au) antigen have been characterized by liquid-phase radioimmunoassay (RIA) for their precipitation of (125)I-labeled Au antigen. The end-point dilutions of sera (anti-Au) which precipitated 50% of (125)I-Au antigen by RIA correlated well with complement fixation titers but had a much wider range, indicating a greater precision and perhaps a better sensitivity o...

Background: Cancer Antigen-125 (CA-125) was first identified as an ovary-specific tumor indicator but subsequently shown that inflammation exists even in the absence of polymorphism leads to this marker rise. Multiple locations tuberculosis (TB) produce increase serum antigen levels. This research objects estimate diagnostic value CA-125 and establish cut-off value, distinguishing tuberculous f...

The aim of this study was to assess the incidence of ovarian cancer in the industrial hub of Uttar Pradesh. A total of 50 samples were collected and estimated for CA-125 by Sandwich Method. CA-125 [Cancer antigen 125 or carbohydrate antigen 125 or Mucin 16] is a high molecular mass glycoprotein recognized by the monoclonal antibody OC 125 and encoded by MUC 16 gene. It contains 24% carbohydrate...

Cancer antigen 125 (CA 125) is a useful tumor marker with a threshold value of 35 U mL(-1) expressed by more than 80% of patients with non-mucinous epithelial ovarian cancer. In this work, a novel strategy for the analysis of CA 125 using the plasmon resonance scattering (PRS) properties of gold nanorods was proposed. The gold nanorod (GNR)-anti-CA 125 conjugates were prepared first. The immuno...