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This is an analysis of fetal outcome in pregnancies exposed to ondansetron to treat Hyperemesis Gravidarum (HG). In this retrospective cohort study, U.S. data on outcome were collected on 1070 pregnancies exposed to ondansetron and compared to outcomes in two control groups: 771 pregnancies in women with a history of HG with no ondansetron exposure and 1555 pregnancies with neither a history of...

macokinetic interactions with many drugs such as dihydropyridine calcium antagonists, including nifedipine (NFP). The plasma concentrations of the drugs increase significantly with GJ intake, and serious adverse reactions may possibly result. Most drugs interacting with GJ are substrates for small intestinal cytochrome P450 (CYP) 3A. That is, GJ– drug interactions are caused by the inhibition o...

ficiency virus (HIV)-1 infection has been advanced by the development of highly active antiretroviral therapy (HAART). HAART reduces plasma HIV-RNA below detectable limits in most cases. However, some patients do not have a sustainable antiviral response, even after experiencing a decrease in plasma HIV-RNA, due to the development of drug resistance and metabolic complications. This undesirable...