The dichloromethane extract of the stem bark of Millettia usaramensis subspecies usaramensis showed anti-plasmodial activity against the chloroquine sensitive (D6) and chloroquine resistant (W2) strains of Plasmodium falciparum. Chromatographic separation of the extract led to the identification of a new rotenoid, (6aR,12aS)-2,3-methylenedioxy-9-methoxy-8-(3,3-dimethylallyl)-12a-hydroxyrotenoid...

Interindividual differences in neuronal wiring may contribute to behavioral individuality and affect susceptibility to neurological disorders. To investigate the causes and potential consequences of wiring variation in Drosophila melanogaster, we focused on a hemilineage of ventral nerve cord interneurons that exhibits morphological variability. We find that late-born subclasses of the 12A hemi...

The nova super-remnant (NSR) surrounding M31N 2008-12a (12a), the annually erupting recurrent (RN), is only known example of this phenomenon. As structure has grown as a result frequent eruptions from 12a, we might expect to see NSRs around other RNe; would confirm RN--NSR association and strengthen connection between novae type Ia supernovae (SN Ia) centered on SN provide lasting, unequivocal ...

We announce here the genome sequencing of Pseudomonas sp. strain 11/12A from Lake Washington sediment. From the genome content, a versatile lifestyle is predicted but not one of bona fide methylotrophy. With the availability of its genomic sequence, Pseudomonas sp. 11/12A presents a prospective model for studying microbial communities in lake sediments.

This study explored transient inactivation of the gene encoding the DNA mismatch repair enzyme MutS as a tool for adaptive evolution of Lactobacillus casei MutS deletion derivatives of L. casei 12A and ATCC 334 were constructed and subjected to a 100-day adaptive evolution process to increase lactic acid resistance at low pH. Wild-type parental strains were also subjected to this treatment. At ...

Pyrrolidines type 2,4-disubstituted (alkyl, aryl or heteroaryl)-6,8-dioxo-3,7-diazabicyclo [3.3.0] octanes (8a-d) were successfully synthesized by an efficient one pot 1,3-dipolar cycloaddition of azomethine ylides (in situ generated from the reaction of aromatic aldehydes and methyl ester of α-amino acids) with dipolarophile (N-phenylmaleimide). The reaction of compounds 8a-d with hydrazine in...

Eight known compounds were isolated from the shrub Tephrosia toxicaria. Among them, 6,7-dimethoxy-chromone (1), was described by the first time from this genus, villosinol (2), which had been previously reported without its 13C-NMR data and sumatrol (3), which has its 13C-NMR data corrected. The antibacterial activity of Tephrosia toxicaria extract and obovatin (6), deguelin (7), 12a-hydroxyα-t...

To search for new targets of anticancer therapies using phytoestrogens we performed comparative metabolic profiling of the breast cancer cell line MCF-7 and the non-tumorigenic breast cell line MCF-12A. Application of gas chromatography-mass spectrometry (GC-MS) revealed significant differences in the metabolic levels after exposure with 17ß-estradiol, genistein or a composition of phytoestroge...

For modeling the topological relations between spatial objects, the concepts of a bound on the intersection of the boundary and interior, and the boundary and exterior are defined in this paper based on the newly developed computational fuzzy topology. Furthermore, the qualitative measures for the intersections are specified based on the a-cut induced fuzzy topology, which are (Aa‘qA)(x),12a an...

Several refinements of norm and numerical radius inequalities bounded linear operators on a complex Hilbert space are given. In particular, we show that if A is operator space, then 14A*A+AA*≤18A+A*2+A−A*2+c2(A+A*)+c2(A−A*)≤w2(A) 12A∗A+AA∗−14(A+A∗)2(A−A∗)212≤w2(A)≤12A∗A+AA∗, where ∥⋅∥, w(⋅) c(⋅) the norm, Crawford number, respectively. Further, prove A, D AD∗≤∫01(1−t)(A2+D2)/2+tAD∗I2dt12≤12A2+D...