Bacterial meningitis is an inflammation of the meninges and subarachnoid space that occurs in response of bacteria. Young children are particularly vulnerable to bacterial meningitis, two thirds of meningitis deaths in low-income countries occur among children under the age of fifteen. The main bacterial pathogens causing meningitis beyond the neonatal period are Streptococcus pneumoniae, Haemo...

Plasma levels of plasminogen activator inhibitor type-1 (PAI1). p-thromboglobulin (pTG), and fibrinopeptide A (FPA) were followed over 24 hours in 30 patients treated with alteplase for acute myocardial infarction. Samples were taken at baseline (T Oh), after 90 minutes (under alteplase, no heparin, T 1.5h). after 120 minutes (under alteplase and heparin, T 2h), 30 minutes after thrombolytic th...

We aimed to determine the effect of relocation whole-plant corn silage (WPCS) with different fermentation profiles on ingestive behavior lambs. Twenty-four male Santa Inês lambs, were used in a completely randomized block design based initial body weight (17.5 ± 1.8 kg) for following treatments: CS: WPCS (not inoculated and not relocated); R-12h: relocated 12h; IR-12h: Lactobacillus plantarum R...

One of the targets of antiretroviral therapy is within cells infected with HIV. In order to improve therapeutic efficacy, it is therefore important that the intracellular pharmacokinetics of drugs, such as nelfinavir mesylate and its active metabolite M8, are studied in addition to plasma pharmacokinetics. Previously, the intracellular accumulation of protease inhibitors has been reported in vi...

Food restriction (FR) seems to be the unique experimental manipulation that leads to a remarkable increase in lifespan in rodents. Evidences have suggested that FR can enhance memory in distinct animal models mainly during aging. However, only few studies systemically evaluated the effects FR on memory formation in both adult (3-month-old) and aged (18-24-month-old) mice. Thus, the aim of the p...

Memory persistence needs a new event of consolidation 12h after the acquisition. We investigated the role of the cholinergic activity on the persistence of memory. For this purpose, we performed the treatments 9 or 12h after acquisition and the memory tested 2 or 7 days after inhibitory avoidance (IA) training. Here we report that activity of medial septum, by transitorily inactivating this str...

A series of naphthopyran derivatives 3a-f were prepared. Reaction of 2-amino-4-(p-chlorophenyl)-7-methoxy-4H-naphtho[2,1-b]pyran-3-carbonitrile (3b) with Ac2O afforded two products, 2-acetylamino-7-methoxy-4-(p-chlorophenyl)-4H-naphtho-[2,1-b]pyran-3-carbonitrile (4) and 10,11-dihydro-3-methoxy-9-methyl-12-(p-chloro-phenyl)-12H-naphtho[2,1-b]pyran[2,3-d]pyrimidine-11-one (5) and treatment of 3b...

The objective of the present study was to describe the trend of germination characteristics for a variety of canola ‘Okapi’ at different pre-soaking durations. For this purpose, seeds were placed in 250 ml of distilled water for 0 to 12h with intervals of 2h at room temperature. Each sample of seed was placed in Petri-dishes and germinated at the temperature of 25°C. Fitting logistic function o...