PURPOSE To quantify the changes of hemoglobin mass (Hbmass) and maximum oxygen consumption (VO2max) after 22 days training at 1300-1800 m combined with nightly exposure to 3000-m simulated altitude. We hypothesized that with simulated 3000-m altitude, an adequate beneficial dose could be as little as 10 h/24 h. METHODS Fourteen male collegiate runners were equally divided into 2 groups: altit...

Using in vitro drug sensitivity data coupled with Affymetrix microarray data, we developed gene expression signatures that predict sensitivity to individual chemotherapeutic drugs. Each signature was validated with response data from an independent set of cell line studies. We further show that many of these signatures can accurately predict clinical response in individuals treated with these d...

Brain metastases are a major cause of mortality in patients with advanced melanoma. Adequate brain distribution of targeted agents for melanoma will be critical for treatment success. Recently, improvement in overall survival led to US Food and Drug Administration (FDA) approval of the v-raf murine sarcoma viral oncogene homolog B (BRAF) inhibitors, vemurafenib and dabrafenib, and the mitogenac...

Acrolein is an electrophilic a,b-unsaturated aldehyde of industrial, pharmaceutic, and toxicologic importance to which we are exposed in environmental, occupational, and therapeutic situations. Acrolein is known to exert different biologic effects through reactions with cellular macromolecules such as DNA, certain proteins, or glutathione. In many situations (such as in tobacco smoke or other f...

Single-phase perovskite solid solutions are formed across the entire (1 − x)Pb(Mg1/3Ta2/3)O3–xLa(Mg2/3Ta1/3)O3 (PLMT) pseudobinary system. Although as-sintered (1300°C, 3 h) samples with x ≤ 0.1 adopt a phase-separated, “PMN-type” microstructure comprising small (2–3 nm) ordered domains dispersed in a disordered matrix, extensive domain growth and complete order can be induced by extended therm...

We present a detailed chemical abundance analysis of HE 1300+0157, a subgiant with [Fe/H] = −3.9. From a high-resolution, high-S/N Subaru/HDS spectrum we find the star to be enriched in C ([C/Fe]1D ∼ +1.4) and O ([O/Fe]1D ∼ +1.8). With the exception of these species, HE 1300+0157 exhibits an elemental abundance pattern similar to that found in many other very and extremely metal-poor stars. The...