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Organic anion transporting polypeptide (Oatp) 1a/1b knockout and OATP1B1 and -1B3 humanized mouse models are promising tools for studying the roles of these transporters in drug disposition. Detailed characterization of these models will help to better understand their utility for predicting clinical outcomes. To advance this approach, we carried out a comprehensive analysis of these mouse line...
Department of Chemistry and Chemica University, Ithaca, New York, 14853-1301, U Department of Physics, University of Cal 94720, USA. E-mail: [email protected] Nuclear Magnetic Resonance Laboratory, Co 1301, USA X-ray Crystallography Laboratory, Cornell USA Department of Chemistry, Northwestern Un † Electronic supplementary information ( For ESI and crystallographic data in CI 10.1039/c6sc025...
of three-dimensional features Chad M. Huard Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Ave., Ann Arbor, Michigan 48109-2122 Yiting Zhang, Saravanapriyan Sriraman, and Alex Paterson Lam Research Corp., 4650 Cushing Parkway, Fremont, California 94538 Mark J. Kushner Department of Electrical Engineering and Computer Science, University of Michigan,...
ONO-1301 [(E)-[5-[2-[1-phenyl-1-(3-pyridyl)methylidene-aminooxy]ethyl]-7,8-dihydronaphthalene-1-yloxy]acetic acid] is a novel prostaglandin (PG) I2 mimetic with inhibitory activity on the thromboxane (TX) A2 synthase. Interestingly, ONO-1301 retains its inhibitory effect on platelet aggregation after repeated administration, while beraprost, a representative agonist for the PGI2 receptor (IP), ...
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1299 Lipoproteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1299 L...
R ea d T ex t C h ap te r 1 R ea d T ex t C h ap te r 2 R ea d T ex t C h ap te r 4 & 5 C o n n ec t M o ti o n ( C h ap te r 2 & 3 ) w it h In te ra ct io n s (C h ap te r 4 & 5 ) u si n g V ec to rs R ea d C P S C h ap te r 4 W o rk ed C P S P ro b le m s C h ap . 3 N ex t 2 W ee ks W o rk p ro b le m s in C h ap te r 4 W o rk p ro b le m s in C h ap te r 5 W o rk p ro b le m s in C P S C h a...
VINEGAR A. Modeling cardiac sensitization potential of humans exposed to Halon 1301 or Halon 1211 aboard aircraft. Aviat Space Environ Med 2001; 72928-36. Background: Halon 1301 and Halon 121 1 are being replaced because they contribute to the depletion of ozone. Many of the potential candidate chemicals for replacing them are, like them, halogenated hydrocarbons. These chemicals have the poten...
Tubulointerstitial injuries are crucial histological alterations that predict the deterioration of renal function in chronic kidney disease. ONO-1301, a novel sustained-release prostacyclin analog, accompanied by thromboxane synthase activity, exerts therapeutic effects on experimental pulmonary hypertension, lung fibrosis, cardiomyopathy, and myocardial ischemia, partly associated with the ind...
[This corrects the article on p. 1301 in vol. 50.].
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