Staged aortic aneurysm repair is one method used to decrease the risk of spinal cord ischemia (SCI) after endovascular intervention. Sequential sacrifice arteries perfusing spine might allow for improved perfusion through development collateral networks over time. To evaluate effect staging repairs on SCI, we conducted a conservative analysis Vascular Quality Initiative data. De-identified data...

Triazoloacridinones (TA) are a new group of potent antitumor compounds, from which the most active derivative, C-1305, has been selected for extended preclinical trials. This study investigated the mechanism of TA binding to DNA. Initially, for selected six TA derivatives differing in chemical structures as well as cytotoxicity and antitumor activity, the capability of noncovalent DNA binding w...

Background: Trop-2 is a well validated oncology therapeutic target. DB-1305 an antibody drug conjugate designed by conjugating anti-Trop-2 with novel topoisomerase I inhibitor P1021 via enzymatically cleavable tetrapeptide linker. Material and Methods: To characterize the payload P1021, thorough studies were performed including in vitro functional assays, vivo efficacy PK/PD murine CDX models, ...

We define an appropriate logarithm function on time scales and present its main properties. This gives answer to a question posed by M. Bohner in [J. Difference Equ. Appl. 11 (2005), no. 15, 1305–1306].

It is well known that ocular bioavailability after topical instillation is extremely low compared with the other administration including oral administration, transdermal application, vitreous injection, and implantable delivery. The ocular bioavailability is also affected by a variety of pharmaceutical factors such as formulation viscosity and the particle size of suspension, and so on. In spi...