A complicating factor in the translational pharmacology of sphingosine 1-phosphate agonists is that they exert their pharmacological effect through their respective phosphate metabolites, which are formed by the enzyme sphingosine kinase (S1PHK). In this investigation, we present a semimechanistic pharmacokinetic model for the interconversion of S1PHK substrates and their respective phosphates ...

OBJECTIVE Religious values were investigated in a group of Iranian Revolutionary Guards in Tehran. METHODS The sample consisted of official duty troops and conscripts who were in prison due to a crime. One hundred thirty seven individuals cooperated with us in the project (37 Official personnel and 100 conscripts). The instruments used included a demographic questionnaire containing personal ...

The art gallery problem is to determine the number of guards that are sufficient to cover or see every point in the interior of an art gallery. An art gallery can be viewed as a polygon P with or without holes with a total of n vertices and guards as points in P . Any point z ∈ P is said to be visible from a guard g if the line segment joining z and g does not intersect the exterior of P . Usua...