Background: MicroRNA (miR) dysregulation is found in Alzheimer's disease (AD). A disintegrin and metalloprotease 10 (ADAM10) prevents generation of amyloid β (Aβ) and decrease AD pathology. Results: miR-144 suppresses ADAM10 expression and is up-regulated by activator protein-1. Conclusion: miR-144 is negative regulator of ADAM10 and may be involved in AD pathogenesis. Significance: The first w...

1. Manifolds: 1/7/14 1 2. Tangent and Cotangent Spaces: 1/9/14 3 3. Vector Fields, One-Forms, and Riemannian Metrics: 1/14/14 6 4. The Lie Bracket and Riemannian Connections: 1/16/14 8 5. Existence and Uniqueness of the Riemannian Connection: 1/21/14 10 6. Tensor Fields, Parallel Transport, and Holonomy: 1/23/14 13 7. The Riemann Curvature Tensor: 1/28/14 15 8. Flatness: 1/30/14 17 9. Symmetrie...

Flexibility vs. Rigidity: Does Spain have the worst of both Worlds? In this paper we study the structure of labor market flows in Spain and compare them with France and the US. We characterize a number of empirical regularities and stylized facts. One striking result is that the job finding rate is slightly higher than in France, while the jon loss rate is much higher, putting Spain half-way be...

Suppose you ran a chess tournament, everybody played everybody, and you wanted to use the results to rank everybody. Unless you were really lucky, the results would not be acyclic, so you could not just sort the players by who beat whom. A natural objective is to find a ranking that minimizes the number of upsets, where an upset is a pair of players where the player ranked lower on the ranking ...

In the book Proofs that Really Count [1], the authors use combinatorial arguments to prove many identities involving Fibonacci numbers, Lucas numbers, and their generalizations. Among these, they derive 91 of the 118 identities mentioned in Vajda’s book [2], leaving 27 identities unaccounted. Eight of these identities, presented later in this paper, have such a similar appearance, the authors r...

The physical reason for aromaticity/antiaromaticity was determined. The conclusion was reached after interpreting Hobey's mathematical results that were given in the study of the energy difference between the one-dimensional linear and cyclic particles-in-a-box models. We first revealed that the Huckel theory and particles-in-a-box model are simply different ways of solving the same Schr6dinger...

Well, someone can decide by themselves what they want to do and need to do but sometimes, that kind of person will need some developing a current awareness service using really simple syndication rss brief communications references. People with open minded will always try to seek for the new things and information from many sources. On the contrary, people with closed mind will always think tha...

The April-June 2006 edition of JSLS contained 2 disturbing papers addressing technical aspects of vascular control in laparoscopic donor nephrectomies. Lallas et al report an algorithm developed during a series of 200 cases performed at the Mayo Clinic in Scottsdale, Arizona in which “early vessel branching or a potential for inadequate vessel length” prompted the use of Hem-o-lok clips on the ...