ThehumanpregnaneX receptor (hPXR) is a xenobiotic-sensing nuclear receptor that transcriptionally regulates drug metabolism–related genes. The aim of the present study was to elucidate the mechanism by which hPXR is regulated through threonine-408. A phosphomimetic mutationat threonine-408 (T408D) reduced the transcriptional activity of hPXR and its protein stability in HepG2 and SW480 cells in...

(This article does not have an abstract.) Toni Dávila George Foster Daniel Oyon “Accounting and control, entrepreneurship and innovation: Venturing into new research opportunities”, European Accounting Review, Vol. 18, No 2, June 2009, pages 281–311. Abstract: The relevance of accounting and control to entrepreneurship and innovation has become more salient over the last few years. The traditio...

A biomaterial derived from porcine intestinal submucosa has been used in the development of a new biologic wound matrix. This review describes the origin of the wound matrix device, including the discovery of the biomaterial and its properties, to the development of the commercial product currently in clinical use. The composition and structure of this biomaterial are described and considered a...

As more horticultural producers in the United States transition to organic production practices, they are challenged in finding consistent and economically viable sources of suitable potting media. Commercial, peat-based media approved for certified organic production are available and custom peat-based mixes that use certified organic fertilizers could also be used. Both of these options, howe...