CONTEXT More than 50% of patients with prostate, breast or lung cancer will develop painful bone metastases. The purpose of treating bone metastases is to relieve pain, reduce the use of steroids and to maintain motion. OBJECTIVE To evaluate the use of samarium-153-EDTMP (153Sm-EDTMP) for the treatment of bone pain secondary to metastases that is refractory to clinical management. TYPE OF S...

introduction: porphyrins are interesting derivatives with low toxicity, tumor avidity and rapid wash-out suggested as potential radiopharmaceuticals in radiolabeled form. in this work we report, synthesis, radiolabeling, quality control, stability, partition coefficient determination and biodistribution studies of 153sm-5,10,15,20-tetrakis(4-methoxyphenyl) porphyrin (153sm-4-mpp) in wild-type r...

Background: The formalism recommended by Task Group 60 (TG-60) of the American Association of Physicists in Medicine (AAPM) is applicable for β sources. Radioactive biocompatible and biodegradable 153Sm glass seed without encapsulation is a β- emitter with a short half life and delivers a high dose rate to the tumor in the millimeter range. In this work the dosimetry parameters of the ...

UNLABELLED The aim of this study was to introduce a new quantification method for 153Sm-ethylenediaminetetramethylenephosphonate (EDTMP) and 186Re-(tin)1,1-hydroxyethylidene diphosphonate (HEDP) to separately measure bone uptake and soft-tissue retention of these radiopharmaceuticals. METHODS Studies were performed on 23 men and 6 women undergoing radionuclide therapy for palliation of bone p...

background: therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153sm]-samarium maltolate was developed for possible therapeutic applications. materials and methods: the or...

Background: Therapeutic radiopharmaceuticals are designed to deliver high doses of radiation to selected target organs with an aim of minimizing unwanted radiation to surrounding healthy tissue. Due to the potential of targeted radiotherapy to treat a wide range of malignant conditions, [153Sm]-samarium maltolate was developed for possible therapeutic applications. Materials and Methods: The or...

Tera Becquerel quantities of a number of radioisotopes such as 131I, 99Mo, 32P, 153Sm, 51Cr, 82Br, 203Hg, 140La, 46Sc, etc. are produced in various radiochemical forms and regularly supplied through Board of Radiation & Isotope Technology (BRIT) for applications in medicine, industry, biology, agriculture and research & development activities. These radioisotopes are produced by neutron activat...

OBJECTIVES This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. MATERIALS AND METHODS The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method. Conjugation was done at a 1: 4 (SPION:ccDTPA) molar ratio. Conjugation reaction was purified with magnetic assorting column (MA...

introduction:targeted radionuclide therapy (trt) has been demonstrated to be an effective therapeutic tool in patients with disseminated bone metastasis. trt is generally performed with a single radionuclide. in this study we investigated the feasibility of combined trt with a high-energy beta emitter (153sm) and a low energy beta emitter (177lu) in wistar rats. methods: the cocktail complex of...

Introduction Compartmental analysis allows the mathematical separation of tissues and organs to determine activity concentration in each point of interest. Biodistribution studies on humans are costly and complicated, whereas such assessments can be easily performed on rodents. In this study, we aimed to develop a pharmacokinetic model of 153Sm-maltolate complex as a novel therapeutic agent and...