نتایج جستجو برای: 17 alpha hydroxyprogesterone caproate

تعداد نتایج: 467684  

2003
Paul J. Meis Mary J. O’Sullivan

From Wake Forest University, WinstonSalem, N.C. (P.J.M.); the National Institute of Child Health and Human Development, Bethesda, Md. (M.K., C.Y.S.); the Biostatistics Center, George Washington University, Rockville, Md. (E.T.); Wayne State University, Detroit (M.P.D.); the University of Tennessee, Memphis (B.S.); the University of Chicago, Chicago (A.H.M.); the University of Alabama, Birmingha...

Journal: :American Journal of Obstetrics and Gynecology 2016

Journal: :American journal of obstetrics and gynecology 2011
Tracy A Manuck Yinglei Lai Paul J Meis Mitchell P Dombrowski Baha Sibai Catherine Y Spong Dwight J Rouse Celeste P Durnwald Steve N Caritis Ronald J Wapner Brian M Mercer Susan M Ramin

OBJECTIVE Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. STUDY DESIGN We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nuc...

Journal: :The New England journal of medicine 2003
Leo R Brancazio Amy P Murtha R Phillps Heine

BACKGROUND Women who have had a spontaneous preterm delivery are at greatly increased risk for preterm delivery in subsequent pregnancies. The results of several small trials have suggested that 17 alpha-hydroxyprogesterone caproate (17P) may reduce the risk of preterm delivery. METHODS We conducted a double-blind, placebo-controlled trial involving pregnant women with a documented history of...

Journal: :American journal of obstetrics and gynecology 2016
John M O'Brien David F Lewis

Progestogens are the first drugs to demonstrate reproducibly a reduction in the rate of early preterm birth. The efficacy and safety of progestogens are related to individual pharmacologic properties of each drug within this class of medication and characteristics of the population that is treated. The synthetic 17-hydroxyprogesterone caproate and natural progesterone have been studied with the...

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