BACKGROUND IFN-α has been used to treat patients with chronic active hepatitis B (CAHB). Recent studies have implicated the IL-23/Th-17 pathway in the pathogenesis of CAHB. In this study, we investigated whether IFN-α could affect this pathway. METHODS Peripheral blood mononuclear cells (PBMCs) obtained from patients with active CAHB (n = 61) and controls (n = 32) were cultured with or withou...

OBJECTIVE The Mycobacterium bovis Bacillus Calmette-Guerin (BCG) neonatal vaccination inhibits allergy-induced pathologic changes. However, the mechanisms underlying this process are unclear. This study aimed to investigate the role of interferon (IFN)-γ and interleukin (IL)-17 in the protective effects of the BCG neonatal vaccination on allergic pulmonary inflammation and airway hyperresponsiv...

Background : Allergic asthma is a chronic inflammatory disease of airway that often determined with degrees of inflammation, hypersensitivity, bronchial constriction and airway changes. Th1, Th2 and Th17 cells are the main cells involved in the pathophysiology of asthma. . Therefore, this study evaluated Th1, Th2, and Th17 cells functions by assessment the expression of INF-g, IL-4, and IL-17 g...

the aim of this study was to investigate the immunomodulatory effects of spirulina platensis (s.platensis) by measuring the levels of serum interleukin (il)-4, il-10, il-17, tumor necrosis factor(tnf)-α and interferon (ifn)-|γ| in mice suffered from systemic candidiasis and breast cancer. theaqueous extract of s. platensis was selected for this study. balb/c female mice were inoculated withcand...

patients and methods in total, 98 samples in four groups (hiv-positive and hiv-negative persons with and without oc) were obtained from the oral cavities and cultured on sabouraud’s dextrose agar and chromagar. also blood samples were obtained to assess plasma level of ifn-γ, il-4, il-6 and il-17 using elisa technique. background cell-mediated immunity (cmi) by cd4 + th (t helper)-type cells is...

Objective(s): Systemic lupus erythematosus (SLE) is a multi-factorial autoimmune disease which may be characterized by T lymphocytes dysfunctions. Th17 cells have been identified as new effector cells, which play an important role in the pathogenesis. In recent years, immunomodulatory effect of vitamin D3 has been noticed. In the present experiment, the effect of vitamin D3 on the expression of...

objective(s):with regard to pharmacological effects of carvacrol on the respiratory system, its effect on cytokines genes expression in splenocytes of asthmatic mice was examined in this study. materials and methods:splenocytes were isolated from non-sensitized (control group), sensitized mice to ovalbumin (ova) (group s), and s animals treated with dexamethasone, and three concentrations of ca...

Inborn errors of TLR3-dependent IFN-α/β– and IFN-λ–mediated immunity in the CNS can underlie herpes simplex virus 1 (HSV-1) encephalitis (HSE). The respective contributions IFN-α/β IFN-λ are unknown. We report a child homozygous for genomic deletion entire coding sequence part 3′-UTR last exon IFNAR1, who died HSE at age 2 years. An older cousin following vaccination against measles, mumps, rub...