OBJECTIVES Polymerized-type I collagen (polymerized collagen) is a downmodulator of inflammation and cartilage regenerator biodrug. AIM To evaluate the effect of intraarticular injections of polymerized collagen after arthroscopic lavage on inflammation and clinical improvement in patients with knee osteoarthritis (OA). METHODS Patients (n = 19) were treated with 6 intraarticular injections...

Previous studies showed that polymerized-type I collagen (polymerized collagen) exhibits potent immunoregulatory properties. This work evaluated the effect of intramuscular administration of polymerized collagen in early and established collagen-induced arthritis (CIA) in mice and analyzed changes in Th subsets following therapy. Incidence of CIA was of 100% in mice challenged with type II coll...

Proliferation and alpha(v)beta(3) integrin-dependent migration of vascular smooth muscle cells are suppressed on polymerized type I collagen. To identify genes specifically regulated in human smooth muscle cells by polymerized collagen, we used the suppressive subtraction hybridization technique. Compared with smooth muscle cells cultured on monomer collagen, polymerized collagen suppresses the...

UNLABELLED Hemoglobin- and catalase-polymerized PEDOT PSS were characterized by X-ray photoelectron spectroscopy, visible and near-IR spectroscopy, FTIR, and ESR. Hemoglobin-polymerized PEDOT PSS possesses bipolarons, while catalase-polymerized PEDOT PSS is dominated by polarons. Use of heme-bound iron as an oxidant yields PEDOT PSS with conductivity of 19.5 S cm(-1) in a single-step aq...

OBJECTIVE Vascular smooth muscle cells (SMCs) cultured on polymerized type I collagen fibrils are arrested in the G1 phase of the cell cycle, and their phenotypic markers and pattern of expressed genes are markedly altered. In this study, we examined polymerized collagen regulation of plasminogen activator inhibitor (PAI)-1 and its involvement in SMC migration. METHODS AND RESULTS We demonstr...

Objective This study investigated the wear resistance of injection-molded thermoplastic denture base resins using nanoindentation instrument. Materials and methods Six injection-molded thermoplastic denture base resins (two polyamides, two polyesters, one polycarbonate, one polymethylmethacrylate [PMMA]) and a PMMA conventional heat-polymerized denture-based polymer control were tested. Elastic...

OBJECTIVE To study the in vitro color changes of three dental resin veneering materials when immersed in tea, coffee and tamarind extracts. MATERIALS AND METHODS The color changes of heat polymerized tooth colored acrylic resin (Stellondetrey, B, F14, DPI Dental products of India Ltd, Mumbai), auto polymerized tooth colored acrylic resin (DPI, B, QV5, DPI Dental products of India Ltd, Mumbai)...

A rapid method for measuring polymerized and depolymerized forms of tubulin in tissues has been developed. The procedure consists of homogenization and centrifugation of the tissue in a microtubule-stabilizing solution and depolymerization of the precipitated microtubules; polymerized and depolymerized forms of tubulin are quantitated by a colchicine-binding assay. The validity of the technique...